Rabbit anti-Human STAT4 Monoclonal Antibody | anti-STAT4 antibody

STAT4 Rabbit mAb

Cat. Num. AAA4754212

• Gene Names: STAT4; SLEB11
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: Affinity purified
• Synonyms: STAT4; Monoclonal Antibody; STAT4 Rabbit mAb; SLEB11; anti-STAT4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 50nM Tris-Glycine(pH7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA

• Applicable Applications for anti-STAT4 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunohistochemistry-Frozen (IHC-F), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Application Notes: WB: 1:1000; IHC: 1:50; ICC/IF: 1:50; FC/FACS: 1:20; IP: 1:20
• Immunogen: A synthetic peptide of human STAT4
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western blot detection of STAT4 in Hela,A549 cell lysates using STAT4 Rabbit mAb(1:1000 diluted).Predicted band size:86kDa.Observed band size:86kDa.)

Immunohistochemistry (IHC)

(Immunohistochemistry of STAT4 in paraffin-embedded Human lung cancer tissue using STAT4 Rabbit mAb at dilution 1/50)

Related Product Information for anti-STAT4 antibody

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Product Categories/Family for anti-STAT4 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 345110660
• NCBI GeneID: 6775
• NCBI Accession #: NP_001230764.1
• NCBI GenBank Nucleotide #: NM_001243835.1
• UniProt Accession #: Q14765; Q96NZ6
• Molecular Weight: 85,941 Da
• NCBI Official Full Name: signal transducer and activator of transcription 4
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 4
• NCBI Official Symbol: STAT4
• NCBI Official Synonym Symbols: SLEB11
• NCBI Protein Information: signal transducer and activator of transcription 4
• UniProt Protein Name: Signal transducer and activator of transcription 4
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT4
• UniProt Entry Name: STAT4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Uniprot Description

STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q32.2-q32.3

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: signal transducer activity; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation

Disease: Systemic Lupus Erythematosus, Susceptibility To, 11