Mouse SNAP25 Monoclonal Antibody | anti-SNAP25 antibody

SNAP25 (Synaptosomal-associated Protein 25, SNAP-25, bA416N4.2, dJ1068F16.2, FLJ23079, HGNC:11132, Resistance to Inhibitors of Cholinesterase 4 Homolog, RIC4, RIC-4, SEC9, SNP25, Super Protein, SUP) (MaxLight 650)

Cat. Num. AAA6256339

• Gene Names: CHGA; CGA
• Reactivity: Hamster, Human, Porcine, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by protein A affinity chromatography from tissue culture supernatant.
• Synonyms: SNAP25; Monoclonal Antibody; SNAP25 (Synaptosomal-associated Protein 25; SNAP-25; bA416N4.2; dJ1068F16.2; FLJ23079; HGNC:11132; Resistance to Inhibitors of Cholinesterase 4 Homolog; RIC4; RIC-4; SEC9; SNP25; Super Protein; SUP) (MaxLight 650); anti-SNAP25 antibody

• Host: Mouse
• Reactivity: Hamster, Human, Porcine, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 3H2886
• Specificity: Recognizes human SNAP-25; an antigen of 26-27kD molecular weight. Will react with SNAP-25 from COS cells, but not with the fusion protein from bacterial systems. Species Crossreactivity: rat, hamster, gerbil and porcine
• Purity/Purification: Purified by protein A affinity chromatography from tissue culture supernatant.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight650.

• Applicable Applications for anti-SNAP25 antibody: FLISA, Immunohistochemistry (IHC), Western Blot (WB)
• Immunogen: Crude human synaptic immunoprecipitate.
• Conjugate: MaxLight650
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Immunohistochemistry (IHC)

(IHC staining of human cerebellar neurons usingMBS608924.)

Product Categories/Family for anti-SNAP25 antibody

Antibodies; Neuroscience

References

1. Honer, W.G., et al., 1994, Hippocampal synaptic pathology in patients with temporal lobe epilepsy. Acta Neuropathol. 87: 202-210. 2. Honer, W.G., et al., 1992, Regional synaptic pathology in Alzheimer's disease. Neurobiol. Aging. 13: 375-382. 3. Honer, W.G., et al., 1993, Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 609: 9-20. 4. Honer, W.G., et al., 1992, Characterization of a synaptic antigen of interest in neuropsychiatric illness. Biol. Phychiatry 31: 147-158. 5. Honer, W.G., et al., 1989, Monoclonal antibodies to study the brain in schizophrenia. Brain Res. 500: 379-383. 6. Masliah, E., et al., 1994, Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus. Acta Neuropathol. 87: 135-142. 7. Simpson, I.A., et al., 1994, Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann Neurol. 35: 546-551. 8. Wakabayashi, K., et al., 1994, Synapse alterations in the hippocampalentorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain Research 667: 24-32. 9. Dickson, D.W., et al., 1994, Hippocampal sclerosis: a common pathological feature of dementia in very old (>80 years of age) humans. Acta Neuropathologica 88: 212-221. 10. Dickson, D.W., et al., 1995, Correlations of synaptic markers with cognitive status in prospectively studied elderly humans. Neurobiol Aging (in press).

NCBI and Uniprot Product Information

• NCBI GI #: 4502805
• NCBI GeneID: 1113
• NCBI Accession #: NP_001266
• NCBI GenBank Nucleotide #: NM_001275.3
• Molecular Weight: 50,688 Da
• NCBI Official Full Name: chromogranin-A isoform 1 preproprotein
• NCBI Official Synonym Full Names: chromogranin A (parathyroid secretory protein 1)
• NCBI Official Symbol: CHGA
• NCBI Official Synonym Symbols: CGA
• NCBI Protein Information: chromogranin-A; SP-I; betagranin (N-terminal fragment of chromogranin A); catestatin; chromofungin; parathyroid secretory protein 1; pituitary secretory protein I
• Protein Family: SNAP25 homologous protein

NCBI Description

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]