Western Blot (WB)
(Western blot analysis using SMAD2 mAb against human SMAD2 (AA)
Mouse anti-Human SMAD2 Monoclonal Antibody | anti-SMAD2 antibody
Anti-SMAD2 Mouse mAb
Western Blot (WB)
(Western blot analysis using SMAD2 mAb against human SMAD2 (AA)
Western Blot (WB)
(Western blot analysis using SMAD2 mAb against human SMAD2 (AA)
Western Blot (WB)
(Western blot analysis using SMAD2 mAb against HEK293 (1) and SMAD2 (AA)
Western Blot (WB)
(Western blot analysis using SMAD2 mAb against HEK293 (1) and SMAD2 (AA)
Immunofluorescence (IF)
(Immunofluorescence analysis of U251 cells using SMAD2 mouse mAb (green). Blue)
Immunofluorescence (IF)
(Immunofluorescence analysis of U251 cells using SMAD2 mouse mAb (green). Blue)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of NIH/3T3 cells using SMAD2 mouse mAb (blue) and negative control (red).)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of NIH/3T3 cells using SMAD2 mouse mAb (blue) and negative control (red).)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using SMAD2 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using SMAD2 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using SMAD2 mouse mAb with DAB staining.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using SMAD2 mouse mAb with DAB staining.)
NCBI and Uniprot Product Information
Uniprot Description
SMAD2: ubiquitously expressed transcription factor phosphorylated and activated by TGF-beta receptor-type kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; double-stranded DNA binding; phosphatase binding; protein binding; SMAD binding; transcription activator binding; transcription factor activity; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding
Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; cell fate commitment; common-partner SMAD protein phosphorylation; gastrulation; mesoderm formation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; palate development; paraxial mesoderm morphogenesis; positive regulation of BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; primary microRNA processing; regulation of binding; regulation of transforming growth factor beta receptor signaling pathway; SMAD protein complex assembly; somatic stem cell maintenance; transforming growth factor beta receptor signaling pathway; zygotic determination of dorsal/ventral axis
Similar Products
Product Notes
The SMAD2 smad2 (Catalog #AAA476193) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-SMAD2 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SMAD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the SMAD2 smad2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SMAD2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
