Western Blot (WB)
(Western Blot detection against Immunogen (33.92kD).)
Mouse anti-Human SLC36A2 Monoclonal Antibody | anti-SLC36A2 antibody
SLC36A2 (Solute Carrier Family 36 Member 2, Proton-coupled Amino Acid Transporter 2, Proton/amino Acid Transporter 2, PAT2, Tramdorin-1, TRAMD1) (AP)
Western Blot (WB)
(Western Blot detection against Immunogen (33.92kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (33.92kD).)
Western Blot (WB)
(SLC36A2 monoclonal antibody. Western Blot analysis of SLC36A2 expression in A-431.)
Western Blot (WB)
(SLC36A2 monoclonal antibody. Western Blot analysis of SLC36A2 expression in A-431.)
NCBI and Uniprot Product Information
Observed: 52 kDa
NCBI Description
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
Uniprot Description
SLC36A2: Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine. Defects in SLC36A2 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC36A2 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Mutations in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families. Belongs to the amino acid/polyamine transporter 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: cytoplasm; integral to membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; glycine transmembrane transporter activity; hydrogen ion transmembrane transporter activity; hydrogen:amino acid symporter activity; L-alanine transmembrane transporter activity; L-proline transmembrane transporter activity
Biological Process: amino acid transport; glycine transport; ion transport; L-alanine transport
Disease: Hyperglycinuria; Iminoglycinuria
Research Articles on SLC36A2
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Product Notes
The SLC36A2 slc36a2 (Catalog #AAA6133826) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SLC36A2 (Solute Carrier Family 36 Member 2, Proton-coupled Amino Acid Transporter 2, Protomino Acid Transporter 2, PAT2, Tramdorin-1, TRAMD1) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC36A2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SLC36A2 slc36a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC36A2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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