Rabbit anti-Mouse SLAMF7/CRACC  Monoclonal Antibody | anti-SLAMF7/CRACC  antibody

Rabbit anti Mouse SLAMF7/CRACC  Monoclonal Antibody

Cat. Num. AAA2544513

• Gene Names: SLAMF7; 19A; CS1; CD319; CRACC
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: SLAMF7/CRACC ; Monoclonal Antibody; Rabbit anti Mouse SLAMF7/CRACC Monoclonal Antibody; anti-SLAMF7/CRACC antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 201

• Applicable Applications for anti-SLAMF7/CRACC antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse SLAMF7. The detection limit for Mouse SLAMF7 is approximately 0.0049 ng/well.
• Immunogen: Recombinant Mouse SLAMF7 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SLAMF7 extracellular domain (rM SLAMF7; NP_653122.2; Met 1-Gly 224).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SLAMF7/CRACC  antibody

SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

NCBI and Uniprot Product Information

• NCBI GI #: 543583709
• NCBI GeneID: 57823
• NCBI GenBank Nucleotide #: NM_001282595.1
• Molecular Weight: 21,316 Da
• NCBI Official Full Name: SLAM family member 7 isoform i
• NCBI Official Synonym Full Names: SLAM family member 7
• NCBI Official Symbol: SLAMF7
• NCBI Official Synonym Symbols: 19A; CS1; CD319; CRACC
• NCBI Protein Information: SLAM family member 7
• UniProt Protein Name: SLAM family member 7
• UniProt Gene Name: SLAMF7
• UniProt Synonym Gene Names: CS1; CRACC
• UniProt Entry Name: SLAF7_HUMAN

Uniprot Description

SLAMF7: Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1-q24.1

Cellular Component: plasma membrane

Biological Process: regulation of immune response