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Western Blot (WB) (Western Blot detection against Immunogen (95.41kD).)

Mouse anti-Human SHC4 Monoclonal Antibody | anti-SHC4 antibody

SHC4 (SHC-transforming Protein 4, Rai-like Protein, RaLP, SHC-transforming Protein D, hShcD, Src Homology 2 Domain-containing-transforming Protein C4, SH2 Domain Protein C4, SHCD, UNQ6438/PRO21364)

Gene Names
SHC4; RaLP; SHCD
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Purified by Protein A affinity chromatography.
Synonyms
SHC4; Monoclonal Antibody; SHC4 (SHC-transforming Protein 4; Rai-like Protein; RaLP; SHC-transforming Protein D; hShcD; Src Homology 2 Domain-containing-transforming Protein C4; SH2 Domain Protein C4; SHCD; UNQ6438/PRO21364); Anti -SHC4 (SHC-transforming Protein 4; anti-SHC4 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
2F5
Specificity
Recognizes human SHC4.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Sequence
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGDKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVEFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRGTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK
Applicable Applications for anti-SHC4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Sandwich ELISA: The detection limit is~10ng/ml as a capture antibody.
Immunogen
Full length recombinant protein corresponding to aa1-631 from human SHC4 (AAH33907) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (95.41kD).)

Western Blot (WB) (Western Blot detection against Immunogen (95.41kD).)

Western Blot (WB)

(SHC4 monoclonal antibody Western Blot analysis of SHC4 expression in human spleen.)

Western Blot (WB) (SHC4 monoclonal antibody Western Blot analysis of SHC4 expression in human spleen.)
Product Categories/Family for anti-SHC4 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
68,785 Da
NCBI Official Full Name
SHC-transforming protein 4
NCBI Official Synonym Full Names
SHC (Src homology 2 domain containing) family, member 4
NCBI Official Symbol
SHC4
NCBI Official Synonym Symbols
RaLP; SHCD
NCBI Protein Information
SHC-transforming protein 4; hShcD; rai-like protein; SH2 domain protein C4; SHC-transforming protein D; src homology 2 domain-containing-transforming protein C4
UniProt Protein Name
SHC-transforming protein 4
Protein Family
UniProt Gene Name
SHC4
UniProt Synonym Gene Names
SHCD; RaLP; hShcD
UniProt Entry Name
SHC4_HUMAN

Uniprot Description

SHC4: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q21.1-q21.2

Cellular Component: postsynaptic membrane; plasma membrane; cell junction

Molecular Function: protein domain specific binding; protein binding; receptor tyrosine kinase binding; protein kinase binding

Biological Process: apoptosis; regulation of gene expression; positive regulation of cell proliferation; stem cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on SHC4

Similar Products

Product Notes

The SHC4 shc4 (Catalog #AAA6006698) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SHC4 (SHC-transforming Protein 4, Rai-like Protein, RaLP, SHC-transforming Protein D, hShcD, Src Homology 2 Domain-containing-transforming Protein C4, SH2 Domain Protein C4, SHCD, UNQ6438/PRO21364) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SHC4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Sandwich ELISA: The detection limit is~10ng/ml as a capture antibody. Researchers should empirically determine the suitability of the SHC4 shc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MRERGQDSLA GLVLYVGLFG HPGMLHRAKY SRFRNESITS LDEGSSGGSV GDKGSPQPPH PALAPHLPTE DATLPSQESP TPLCTLIPRM ASMKLANPAT LLSLKNFCLG TKEVPRLKLQ ESRDPGSSGP SSPETSLSRS GTAPPPQQDL VGHRATALTP DSCPLPGPGE PTLRSRQDRH FLQHLLGMGM NYCVRYMGCV EVLQSMRSLD FGMRTQVTRE AISRLCEAVP GANGAIKKRK PPVEFLSTVL GKSNLQFSGM NIKLTISTCS LTLMNLDNQQ IIANHHMQSI SFASGGDPDT TDYVAYVAKD PVNQRACHIL ECHNGMAQDV ISTIGQAFEL RFKQYLKNPS LNTSCESEEV HIDSHAEERE DHEYYNEIPG KQPPVGGVSD MRIKVQATEQ MAYCPIQCEK LCYLPGNSKC SSVYENCLEQ SRAIGNVHPR GVQSQRGTSL LKHTCRVDLF DDPCYINTQA LQSTPGSAGN QRSAQPLGSP WHCGKAPETV QPGATAQPAS SHSLPHIKQQ LWSEECYHGK LSRKAAESLL VKDGDFLVRE SATSPGQYVL SGLQGGQAKH LLLVDPEGKV RTKDHVFDNV GHLIRYHMDN SLPIISSGSE VSLKQPVRKD NNPALLHSNK. It is sometimes possible for the material contained within the vial of "SHC4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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