Mouse anti-Human SARM Monoclonal Antibody | anti-SARM1 antibody

SARM (SAM and ARM-containing Protein)

Cat. Num. AAA602261

• Gene Names: SARM1; SARM; SAMD2; MyD88-5
• Reactivity: Human
• Applications: Immunoprecipitation
• Purity: Highly Purified; >95% (SDS-PAGE)
• Synonyms: SARM; Monoclonal Antibody; SARM (SAM and ARM-containing Protein); Anti -SARM (SAM and ARM-containing Protein); anti-SARM1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 6D754
• Specificity: Recognizes human SARM.
• Purity/Purification: Highly Purified; >95% (SDS-PAGE)
• Form/Format: Supplied as a liquid in PBS, 10% glycerol, 0.02% sodium azide.

• Applicable Applications for anti-SARM1 antibody: Immunoprecipitation (IP)
• Application Notes: Suitable for use in Immunoprecipitation. Not suitable for Western Blot.; Dilution: Immunoprecipitation: 1:200
• Immunogen: Recombinant human SARM (aa 93-292).
• Preparation and Storage: For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-SARM1 antibody

Antibodies; Abs to Toll Like Receptors (TLR)

NCBI and Uniprot Product Information

• NCBI GI #: 154090976
• NCBI GeneID: 23098
• NCBI Accession #: NP_055892.2
• NCBI GenBank Nucleotide #: NM_015077.3
• UniProt Accession #: Q6SZW1; O60277; Q7LGG3; Q9NXY5
• Molecular Weight: 79,388 Da
• NCBI Official Full Name: sterile alpha and TIR motif-containing protein 1
• NCBI Official Synonym Full Names: sterile alpha and TIR motif containing 1
• NCBI Official Symbol: SARM1
• NCBI Official Synonym Symbols: SARM; SAMD2; MyD88-5
• NCBI Protein Information: sterile alpha and TIR motif-containing protein 1; tir-1 homolog; SAM domain-containing protein 2; sterile alpha and Armadillo repeat protein; sterile alpha motif domain-containing protein 2; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
• UniProt Protein Name: Sterile alpha and TIR motif-containing protein 1
• Protein Family: Sterile alpha and TIR motif-containing protein
• UniProt Gene Name: SARM1
• UniProt Synonym Gene Names: KIAA0524; SAMD2; SARM; MyD88-5
• UniProt Entry Name: SARM1_HUMAN

Uniprot Description

SARM1: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: microtubule; mitochondrion; axon; cytoplasm; dendrite; extrinsic to mitochondrial outer membrane; synapse; cell junction; cytosol

Biological Process: regulation of apoptosis; MyD88-independent toll-like receptor signaling pathway; regulation of dendrite morphogenesis; toll-like receptor signaling pathway; response to glucose stimulus; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway