Mouse anti-Human, Mouse RIT2 / RIN Monoclonal Antibody | anti-RIT2 antibody

Mouse Monoclonal [clone 27G2] (IgG2b)

Cat. Num. AAA245743

• Gene Names: RIT2; RIN; RIBA; ROC2
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Sterile filtered
• Synonyms: RIT2 / RIN; Monoclonal Antibody; Mouse Monoclonal [clone 27G2] (IgG2b); Anti-RIT2 / RIN Antibody (clone 27G2) IHC-plus; RIT2; RIN; Ras-like without CAAX 2; RIBA; GTP-binding protein Rit2; GTP-binding protein Roc2; Ric-like; expressed in neurons; ROC2; anti-RIT2 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 27G2
• Purity/Purification: Sterile filtered
• Form/Format: 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol at pH 7.5 and 3 mM sodium azide. Sourced in TCS.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 217

• Applicable Applications for anti-RIT2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:50), WB
• Immunogen Description: Full-length recombinant human Rin protein
• Preparation and Storage: Store at -20 degree C. Aliquot to avoid freeze/thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-RIT2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)

Western Blot (WB)

(Western blot of Rin antibody () on 293 cells expressing HA-tagged Rit (1) and HA-tagged Rin (2).)

Product Categories/Family for anti-RIT2 antibody

Family: Ras GTPase superfamily IPR001806

NCBI and Uniprot Product Information

• NCBI GI #: 4506533
• NCBI GeneID: 6014
• NCBI Accession #: NP_002921.1
• NCBI GenBank Nucleotide #: NM_002930.3
• UniProt Accession #: Q99578; O15295; Q8TD69; Q8WVF6; Q92964; B2R9L1
• Molecular Weight: 17,308 Da
• NCBI Official Full Name: GTP-binding protein Rit2 isoform 1
• NCBI Official Synonym Full Names: Ras-like without CAAX 2
• NCBI Official Symbol: RIT2
• NCBI Official Synonym Symbols: RIN; RIBA; ROC2
• NCBI Protein Information: GTP-binding protein Rit2; GTP-binding protein Roc2; Ric-like, expressed in neurons; ras-like without CAAX protein 2; ras-like protein expressed in neurons
• UniProt Protein Name: GTP-binding protein Rit2
• Protein Family: GTP-binding protein
• UniProt Gene Name: RIT2
• UniProt Synonym Gene Names: RIN; ROC2
• UniProt Entry Name: RIT2_HUMAN

NCBI Description

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

Uniprot Description

RIT2: Binds and exchanges GTP and GDP. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein; G protein, monomeric, Ras; G protein, monomeric

Chromosomal Location of Human Ortholog: 18q12.3

Cellular Component: plasma membrane; nucleus

Molecular Function: GTPase activity; calmodulin binding; GTP binding

Biological Process: synaptic transmission; nerve growth factor receptor signaling pathway; metabolic process; small GTPase mediated signal transduction; signal transduction