Immunohistochemistry (IHC)
(IHC with RIPK2 antibody on frozen human pancreas.)
Mouse anti-Human RICK / RIP2 / CCK Monoclonal Antibody | anti-RICK antibody
Mouse Monoclonal [clone 7F5] (IgG1,k) to Human RICK / RIP2 / CCK
Usage: Immunohistochemistry: Frozen. Sandwich ELISA: Recombinant protein. Western Blot: Cell lysate, Recombinant protein.
Immunohistochemistry (IHC)
(IHC with RIPK2 antibody on frozen human pancreas.)
Immunohistochemistry (IHC)
(IHC with RIPK2 antibody on frozen human pancreas.)
Western Blot (WB)
(RIPK2 monoclonal antibody, clone 7F5 Western blot of RIP2 expression in HeLa.)
Western Blot (WB)
(RIPK2 monoclonal antibody, clone 7F5 Western blot of RIP2 expression in HeLa.)
ELISA (EIA)
(Detection limit for recombinant GST tagged RIPK2 is approximately 0.1 ng/ml as a capture antibody.)
ELISA (EIA)
(Detection limit for recombinant GST tagged RIPK2 is approximately 0.1 ng/ml as a capture antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Uniprot Description
RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.10.2; TKL group; RIPK family
Chromosomal Location of Human Ortholog: 8q21
Cellular Component: protein complex; cytoskeleton; cytoplasm; cytosol; vesicle
Molecular Function: protein serine/threonine kinase activity; LIM domain binding; protein binding; signal transducer activity; protein homodimerization activity; non-membrane spanning protein tyrosine kinase activity; CARD domain binding; ATP binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; activation of MAPK activity; apoptosis; positive regulation of interleukin-12 production; positive regulation of apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; toll-like receptor 3 signaling pathway; signal transduction; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; T cell proliferation; response to exogenous dsRNA; positive regulation of immature T cell proliferation; positive regulation of interferon-beta production; lipopolysaccharide-mediated signaling pathway; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; adaptive immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-serine phosphorylation; positive regulation of chemokine production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein ubiquitination; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of alpha-beta T cell proliferation; toll-like receptor 9 signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of cytokine and chemokine mediated signaling pathway; negative regulation of apoptosis
Research Articles on RICK
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Product Notes
The RICK ripk2 (Catalog #AAA249023) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal [clone 7F5] (IgG1,k) to Human RICK / RIP2 / CCK reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RICK / RIP2 / CCK can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Frozen), Western Blot (WB), ELISA (EIA). ELISA, IHC-Fr (1:50), WB Usage: Immunohistochemistry: Frozen. Sandwich ELISA: Recombinant protein. Western Blot: Cell lysate, Recombinant protein. Researchers should empirically determine the suitability of the RICK ripk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RICK / RIP2 / CCK, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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