Mouse anti-Human RELB Monoclonal Antibody | anti-RELB antibody

Anti-RELB Mouse mAb

Cat. Num. AAA476569

• Gene Names: RELB; IREL; I-REL; REL-B
• Reactivity: Human
• Applications: Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Ascitic Fluid
• Synonyms: RELB; Monoclonal Antibody; Anti-RELB Mouse mAb; IREL; I-REL; REL-B; anti-RELB antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 2E4B1
• Purity/Purification: Ascitic Fluid
• Form/Format: Purified antibody in PBS with 0.05% sodium azide.

• Applicable Applications for anti-RELB antibody: Immunohistochemistry Paraffin (IHC-P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (FC/FACS)
• Immunogen: Purified recombinant fragment of human RELB (AA: 273-443) expressed in E Coli.
• Conjugation: Unconjugated
• Antibody Type: Flowcytometry
• Subcellular location: Cytoplasm, Cytoskeleton, Nucleus.
• Preparation and Storage: Store at 4°C short term. Store at -20°C long term. ; Avoid freeze / thaw cycle.

Western Blot (WB)

(Western blot analysis using RELB mAb against human RELB (AA)

Western Blot (WB)

(Western blot analysis using RELB mAb against HEK293 (1) and RELB (AA)

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF-7 cells using RELB mouse mAb (green). Blue)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of MCF-7 cells using RELB mouse mAb (green) and negative control (red).)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using RELB mouse mAb with DAB staining.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using RELB mouse mAb with DAB staining.)

Related Product Information for anti-RELB antibody

Entrez Summary: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment

NCBI and Uniprot Product Information

• NCBI GI #: 765526931
• NCBI GeneID: 5971
• UniProt Accession #: Q01201; Q6GTX7; Q9UEI7
• Molecular Weight: 62.1
• NCBI Official Full Name: RelB (plasmid)
• NCBI Official Synonym Full Names: RELB proto-oncogene, NF-kB subunit
• NCBI Official Symbol: RELB
• NCBI Official Synonym Symbols: IREL; I-REL; REL-B
• NCBI Protein Information: transcription factor RelB
• UniProt Protein Name: Transcription factor RelB
• Protein Family: Antitoxin
• UniProt Gene Name: RELB

Uniprot Description

RELB: a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: chromatin binding; protein binding; transcription corepressor activity; transcription factor activity

Biological Process: circadian regulation of gene expression; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; response to cytokine stimulus; stimulatory C-type lectin receptor signaling pathway