Mouse PRSS12 Monoclonal Antibody | anti-PRSS12 antibody

PRSS12 (Protease, Serine, 12 (neurotrypsin, motopsin), BSSP-3, BSSP3, MGC12722, MRT1) (Biotin)

Cat. Num. AAA6174246

• Gene Names: PRSS12; MRT1; BSSP3; BSSP-3
• Applications: Western Blot
• Purity: Purified
• Synonyms: PRSS12; Monoclonal Antibody; PRSS12 (Protease; Serine; 12 (neurotrypsin; motopsin); BSSP-3; BSSP3; MGC12722; MRT1) (Biotin); Protease; MRT1; anti-PRSS12 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 1C3
• Specificity: Recognizes PRSS12.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-PRSS12 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: PRSS12 (NP_003610.1, 541aa-640aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: LGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRG
• Conjugate: Biotin
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Detection limit for recombinant GST tagged PRSS12 is 0.03 ng/ml as a capture antibody.)

Related Product Information for anti-PRSS12 antibody

This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. [provided by RefSeq]

Product Categories/Family for anti-PRSS12 antibody

Antibodies; Enzymes; Protease (Proteinase; Peptidase)

NCBI and Uniprot Product Information

• NCBI GI #: 4506143
• NCBI GeneID: 8492
• NCBI Accession #: NP_003610.1
• NCBI GenBank Nucleotide #: NM_003619.2
• UniProt Accession #: P56730; Q9UP16
• Molecular Weight: 97,067 Da
• NCBI Official Full Name: neurotrypsin
• NCBI Official Synonym Full Names: protease, serine, 12 (neurotrypsin, motopsin)
• NCBI Official Symbol: PRSS12
• NCBI Official Synonym Symbols: MRT1; BSSP3; BSSP-3
• NCBI Protein Information: neurotrypsin; leydin; brain-specific serine protease 3
• UniProt Protein Name: Neurotrypsin
• Protein Family: Neurotrypsin
• UniProt Gene Name: PRSS12
• UniProt Entry Name: NETR_HUMAN

NCBI Description

This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]

Uniprot Description

PRSS12: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Defects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the peptidase S1 family.

Protein type: Protease; Vesicle; EC 3.4.21.-; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q28.1

Cellular Component: axon; dendrite; extracellular region; plasma membrane; terminal button; cytoplasmic vesicle

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; exocytosis; zymogen activation; proteolysis

Disease: Mental Retardation, Autosomal Recessive 1