Mouse anti-Human Prostate Secretory Protein Monoclonal Antibody | anti-MSMB antibody
Prostate Secretory Protein (PSP)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq]
Uniprot Description
MSMB: Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the beta-microseminoprotein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: extracellular space; nucleus
Disease: Prostate Cancer, Hereditary, 13
Research Articles on MSMB
2. A single-nucleotide polymorphism in the MSMB promoter contributes to the genetic predisposition to prostate cancer in the southern Chinese Han population.
3. Crystal structure shows that these edges from two PSP94 monomers associate in antiparallel fashion, leading to formation of a dimer.
4. We conclude that MSMB is unlikely to be a familial prostate cancer gene.The high-risk alleles may effect prostate cancer risk by modifying MSMB gene expression in response to hormones in a tissue-specific manner.
5. For the two SNPs that had significant differences between more and less aggressive disease, KLK3 and MSMB, the alleles that are associated with increased risk for prostate cancer were more frequent in patients with less aggressive disease.
6. a common variant in MSMB on chromosome 10q11.2 is associated with prostate cancer susceptibility
7. beta-Microseminoprotein was purified using anion-exchange and size-exclusion chromatography and the purified protein was crystallized using 0.1 M ammonium sulfate, 0.1 M HEPES buffer pH 7.0 and 20%(w/v) PEG 3350
8. The observations that rs10993994 is the strongest associated variant in the region and its risk allele has a major effect on the transcriptional activity of MSMB suggest the T allele as a causal variant that confers increased risk of prostate cancer.
9. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
10. PSP94 has been purified from human seminal plasma and crystallized.
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Product Notes
The MSMB msmb (Catalog #AAA606870) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Prostate Secretory Protein (PSP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Prostate Secretory Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Immunoperoxidase staining, Western Blot and ELISA. Researchers should empirically determine the suitability of the MSMB msmb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Prostate Secretory Protein, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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