Western Blot (WB)
(Western blot detection of PRMT1 in Hela, A549 and SW480 cell lysates using PRMT1 mouse mAb (1:1000 diluted).Predicted band size:42KDa.Observed band size:42KDa.)
anti-Human PRMT1 Monoclonal Antibody | anti-PRMT1 antibody
Anti-PRMT1 Mouse mAb
Source: Human
Western Blot (WB)
(Western blot detection of PRMT1 in Hela, A549 and SW480 cell lysates using PRMT1 mouse mAb (1:1000 diluted).Predicted band size:42KDa.Observed band size:42KDa.)
Western Blot (WB)
(Western blot detection of PRMT1 in Hela, A549 and SW480 cell lysates using PRMT1 mouse mAb (1:1000 diluted).Predicted band size:42KDa.Observed band size:42KDa.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
Uniprot Description
PRMT1: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP. Widely expressed. By BTG1, BTG2 and ILF3. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.125; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: enzyme binding; histone methyltransferase activity; identical protein binding; methyl-CpG binding; methyltransferase activity; mitogen-activated protein kinase p38 binding; N-methyltransferase activity; protein binding; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity
Biological Process: cell surface receptor linked signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; histone methylation; negative regulation of megakaryocyte differentiation; neurite development; peptidyl-arginine methylation; positive regulation of erythrocyte differentiation; positive regulation of hemoglobin biosynthetic process; protein amino acid methylation; regulation of transcription, DNA-dependent
Research Articles on PRMT1
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Product Notes
The PRMT1 prmt1 (Catalog #AAA475090) is an Antibody produced from Mouse Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti-PRMT1 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PRMT1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the PRMT1 prmt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRMT1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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