Rat PLVAP Monoclonal Antibody | anti-PLVAP antibody
RAT ANTI MOUSE PLVAP
Gene Names
Plvap; Pv1; MECA32
Applications
Immunohistochemistry, Flow Cytometry, Functional Assay
Synonyms
PLVAP; Monoclonal Antibody; RAT ANTI MOUSE PLVAP; anti-PLVAP antibody
Host
Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
MECA-32
Form/Format
Purified
Purified IgG - liquid
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (varies by lot)
Sequence Length
438
Applicable Applications for anti-PLVAP antibody
Immunohistology Frozen, Flow cytometry (FC/FACS)
Application Notes
Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/100
Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/100
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Preparation
Fusion Partners
Spleen cells from immunised rat were fused with cells of the Sp2/0 myeloma cell line.
Buffer Solution
Buffer Solution
Target Species
Mouse
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Shelf Life: 18 months from date of despatch.
Related Product Information for anti-PLVAP antibody
Rat anti Mouse PLVAP antibody, clone MECA-32 recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,933 Da
NCBI Official Full Name
plasmalemma vesicle-associated protein
NCBI Official Synonym Full Names
plasmalemma vesicle associated protein
NCBI Official Symbol
Plvap
NCBI Official Synonym Symbols
Pv1; MECA32
NCBI Protein Information
plasmalemma vesicle-associated protein; MECA-32 antigen; plasmalemma vesicle protein 1
UniProt Protein Name
Plasmalemma vesicle-associated protein
Protein Family
UniProt Gene Name
Plvap
UniProt Synonym Gene Names
Pv1; PV-1
UniProt Entry Name
PLVAP_MOUSE
Uniprot Description
PLVAP: Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: cell surface; membrane; cytoplasm; integral to membrane; plasma membrane; caveola; intracellular
Molecular Function: protein homodimerization activity
Biological Process: positive regulation of cellular extravasation; tumor necrosis factor-mediated signaling pathway; MAPKKK cascade
Research Articles on PLVAP
Similar Products
Product Notes
The PLVAP plvap (Catalog #AAA214383) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PLVAP can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen, Flow cytometry (FC/FACS). Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Immunohistology - Frozen: Minimum Dilution: 1/25; Maximum Dilution: 1/100. Researchers should empirically determine the suitability of the PLVAP plvap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLVAP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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