Rat anti-Mouse Plexin A1 Monoclonal Antibody | anti-PLXNA1 antibody

Plexin A1

Cat. Num. AAA600609

• Gene Names: PLXNA1; NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
• Reactivity: Mouse
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Plexin A1; Monoclonal Antibody; Anti -Plexin A1; anti-PLXNA1 antibody

• Host: Rat
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 7H233
• Specificity: Recognizes mouse Plexin A1.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.

• Applicable Applications for anti-PLXNA1 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: Immunohistochemistry: 10ug/ml
• Immunogen: E. coli-derived recombinant mouse Plexin A1 (aa49-165) Accession # P70206
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-PLXNA1 antibody

Plexin-A1 is an 1894 amino acid, 200kD type I transmembrane protein that is a member of the Plexin family of semaphorin signal transducers. Plexin-A1 binds the transmembrane Sema6D directly and binds the Class 3 secreted semaphorins indirectly via neuropilin-1 and 2. It mediates cytoskeletal remodeling that results in cell migration and axon repulsion. In the region used as an immunogen, mouse and human Plexin A1 share 97% amino acid identity.

Product Categories/Family for anti-PLXNA1 antibody

Antibodies; Abs to Plexin; Semaphorin

NCBI and Uniprot Product Information

• NCBI GI #: 119599757
• NCBI GeneID: 5361
• UniProt Accession #: Q9UIW2; Q6ZTY7; Q9NSM6
• Molecular Weight: 211,067 Da
• NCBI Official Full Name: plexin A1, isoform CRA_c
• NCBI Official Synonym Full Names: plexin A1
• NCBI Official Symbol: PLXNA1
• NCBI Official Synonym Symbols: NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
• NCBI Protein Information: plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV
• UniProt Protein Name: Plexin-A1
• Protein Family: Plexin
• UniProt Gene Name: PLXNA1
• UniProt Synonym Gene Names: NOV; PLXN1
• UniProt Entry Name: PLXA1_HUMAN

Uniprot Description

PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: semaphorin receptor activity; receptor activity

Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development