Dilution Information
Rabbit anti-Human, Mouse PHOX2B Monoclonal Antibody | anti-PHOX2B antibody
PHOX2B (EP312)
Reactivity
Human, Mouse
Synonyms
PHOX2B; Monoclonal Antibody; PHOX2B (EP312); paired like homeobox 2b; NBLST2; NBPhox; PMX2B; neuroblastoma paired type homeobox protein; Neuroblastoma Phox; paired mesoderm homeobox 2b; Paired mesoderm homeobox protein 2B; Paired like homeobox 2B; PHOX2B homeodomain protein; anti-phox2b; anti phox2b; anti-phox; anti phox; anti-PHOX2B antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP312
Form/Format
Paraffin, Frozen
PHOX2B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
PHOX2B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues of human PHOX2B protein.
Control
Adrenal, Neuroblastoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(PHOX2B Antibody Immunohistochemistry on an FFPE Neuroblastoma Tissue)
Immunohistochemistry (IHC)
(PHOX2B Antibody Immunohistochemistry on an FFPE Neuroblastoma Tissue)
Related Product Information for anti-PHOX2B antibody
Paired-like homeobox 2b (PHOX2B), also known as neuroblastoma Phox (NBPhox), is a protein that in humans is encoded by the PHOX2B gene located on chromosome 4. It is expressed exclusively in the nervous system, in most neurons that control the viscera (cardiovascular, digestive and respiratory systems). It is also required for neuron differentiation. Mutations in human PHOX2B cause a rare disease of the autonomic nervous system (dysautonomia): congenital central hypoventilation syndrome (associated with respiratory arrests during sleep and, occasionally, wakefulness), Hirschsprung's disease (partial agenesis of the enteric nervous system), ROHHAD, and tumors of the sympathetic ganglia.
PHOX2 gene over-expression in Neuroblastoma (NB) tumors and cell lines suggests these genes may be widely involved in Neuroblastoma development through either a direct mechanism of up-regulation or a failure in maintaining proper transcript levels after embryonic development. The PHOX2B antibody expression has been observed in all peripheral neuroblastic tumors, paragangliomas, and pheochromocytomas tested but in no other pediatric tumors among the 388 cases studied by expression microarray and the 109 cases studied by immunohistochemical analysis. PHOX2B and CD57 have been found to be useful markers of Neuroblastoma. PHOX2B antibody is specific for Neuroblastoma in its differential identification with other small round cell tumors, and its nuclear staining may be helpful for accurate bone marrow tumor quantification.
PHOX2 gene over-expression in Neuroblastoma (NB) tumors and cell lines suggests these genes may be widely involved in Neuroblastoma development through either a direct mechanism of up-regulation or a failure in maintaining proper transcript levels after embryonic development. The PHOX2B antibody expression has been observed in all peripheral neuroblastic tumors, paragangliomas, and pheochromocytomas tested but in no other pediatric tumors among the 388 cases studied by expression microarray and the 109 cases studied by immunohistochemical analysis. PHOX2B and CD57 have been found to be useful markers of Neuroblastoma. PHOX2B antibody is specific for Neuroblastoma in its differential identification with other small round cell tumors, and its nuclear staining may be helpful for accurate bone marrow tumor quantification.
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Product Notes
The PHOX2B (Catalog #AAA370442) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PHOX2B (EP312) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "PHOX2B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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