Mouse anti-Rat Phosphacan Monoclonal Antibody | anti-PTPRZ1 antibody

Phosphacan (Receptor Tyrosine Phosphatase beta)

Cat. Num. AAA602167

• Gene Names: PTPRZ1; PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
• Reactivity: Rat
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry
• Purity: Ascites; Ascites
• Synonyms: Phosphacan; Monoclonal Antibody; Phosphacan (Receptor Tyrosine Phosphatase beta); Anti -Phosphacan (Receptor Tyrosine Phosphatase beta); anti-PTPRZ1 antibody

• Host: Mouse
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: IgM
• Clone Number: 2Q134
• Specificity: Recognizes the core protein of rat Phosphacan (Receptor Tyrosine Phosphatase Beta).
• Purity/Purification: Ascites; Ascites
• Form/Format: Supplied as a liquid. No preservatives added.

• Applicable Applications for anti-PTPRZ1 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Immunoprecipitation.; Dilution: Immunocytochemistry: 1:10; Immunohistochemistry (4% Paraformaldehyde fixed): 1:1000 Western Blot: Recognizes bands at 250, 190 and 180kD from embryonic rat brain extracts.
• Immunogen: Phosphacan
• Positive Control: Embryonic or early post-natal rat brain.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Immunohistochemistry: Phosphacan (Receptor Tyrosine Phosphatase beta) MBS602167 staining of adult rat hippocampus. Photo shows dentate gyrus.)

Related Product Information for anti-PTPRZ1 antibody

Phosphacan is a soluble nervous tissue-specific proteoglycan that is thought to regulate axonal outgrowth. It is synthesized by glia. It inds to neurons and to the neural cell adhesion molecules tenascin, N-CAM or NG-CAM. It does not bind to laminin and fibronectin. Phosphacan acts as a potent inhibitor of cell adhesion and neurite outgrowth.

Product Categories/Family for anti-PTPRZ1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 530386271
• NCBI GeneID: 5803
• NCBI Accession #: XP_005250576.1
• NCBI GenBank Nucleotide #: XM_005250519.1
• UniProt Accession #: P23471; O76043; Q9UDR6; A4D0W5
• Molecular Weight: 254,587 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase zeta isoform X1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor-type, Z polypeptide 1
• NCBI Official Symbol: PTPRZ1
• NCBI Official Synonym Symbols: PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase zeta; receptor-type tyrosine phosphatase beta/zeta; protein-tyrosine phosphatase receptor type Z polypeptide 2; protein tyrosine phosphatase, receptor-type, zeta polypeptide 1
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase zeta
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRZ1
• UniProt Synonym Gene Names: HTPZP2; PTPRZ; PTPRZ2; PTPZ; R-PTP-zeta
• UniProt Entry Name: PTPRZ_HUMAN

NCBI Description

This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Description

PTPRZ1: May be involved in the regulation of specific developmental processes in the CNS. Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: learning and/or memory; central nervous system development; axonogenesis; oligodendrocyte differentiation; hemopoietic progenitor cell differentiation; protein amino acid dephosphorylation

Disease: Helicobacter Pylori Infection, Susceptibility To