PD-L2 recombinant antibody
Anti-PD-L2 [TY25]
Gene Names
Pdcd1lg2; Btdc; B7-DC; PD-L2; F730015O22Rik
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
Purity
Protein A Affinity Purified
Synonyms
PD-L2; Monoclonal Recombinant Antibody; Anti-PD-L2 [TY25]; B7-DC; PDL2; B7DC; CD273; programmed death ligand 2; Pdcd1lg2; PD-L2 recombinant antibody
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat IgG2a, Kappa
Clone Number
TY25
Specificity
This antibody binds to mouse PD-L2 and competes with PD-1 binding. It does not cross-react with PD-L1.
Purity/Purification
Protein A Affinity Purified
Concentration
1 mg/ml (varies by lot)
Sequence Length
247
Applicable Applications for PD-L2 recombinant antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Block (BL)
Application Notes
This antibody has been used to detect murine PD-L2 by flow cytometry on stimulated dendritic cells as well as various mouse tumour cells. It also detects immunoprecipitates mouse PD-L2 and can be used to detect it by non-reducing Western Blot. TY25 inhibits PD-L2 binding to PD-1 transfected cells and thereby blocks PD-L2: PD-1 signalling.
Immunogen
This antibody was raised by immunising SD rats with B7-DC-transfected RAW264.7 cells and selected on B7-DC-transfected NRK.
Buffer Composition
PBS only with 0.02% Proclin 300.
Labeled Substance
None
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Related Product Information for PD-L2 recombinant antibody
Recombinant monoclonal antibody to PD-L2. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the hybridoma TY25.
This antibody was raised by immunising SD rats with B7-DC-transfected RAW264.7 cells and selected on B7-DC-transfected NRK.
This antibody was raised by immunising SD rats with B7-DC-transfected RAW264.7 cells and selected on B7-DC-transfected NRK.
Product Categories/Family for PD-L2 recombinant antibody
References
Yamazaki et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol. 2002 Nov 15; 169(10):5538-45 PMID:12421930
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,820 Da
NCBI Official Full Name
programmed cell death 1 ligand 2
NCBI Official Synonym Full Names
programmed cell death 1 ligand 2
NCBI Official Symbol
Pdcd1lg2
NCBI Official Synonym Symbols
Btdc; B7-DC; PD-L2; F730015O22Rik
NCBI Protein Information
programmed cell death 1 ligand 2
UniProt Protein Name
Programmed cell death 1 ligand 2
UniProt Gene Name
Pdcd1lg2
UniProt Synonym Gene Names
B7dc; Btdc; Cd273; Pdl2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC
Uniprot Description
Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Research Articles on PD-L2
Similar Products
Product Notes
The PD-L2 pdcd1lg2 (Catalog #AAA488370) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-PD-L2 [TY25] reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PD-L2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Block (BL). This antibody has been used to detect murine PD-L2 by flow cytometry on stimulated dendritic cells as well as various mouse tumour cells. It also detects immunoprecipitates mouse PD-L2 and can be used to detect it by non-reducing Western Blot. TY25 inhibits PD-L2 binding to PD-1 transfected cells and thereby blocks PD-L2: PD-1 signalling. Researchers should empirically determine the suitability of the PD-L2 pdcd1lg2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PD-L2, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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