Western Blot (WB)
(Western blot analysis of 624 Mel nuclear lysates probed with Pax-3 mAb (C2) at 1µg/ml)
Mouse anti-Human Pax3 Monoclonal Antibody | anti-PAX3 antibody
Pax3 monoclonal antibody (C2)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~53kDa by Western blot.
Avoid freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of 624 Mel nuclear lysates probed with Pax-3 mAb (C2) at 1µg/ml)
Western Blot (WB)
(Western blot analysis of 624 Mel nuclear lysates probed with Pax-3 mAb (C2) at 1µg/ml)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]
Uniprot Description
PAX3: Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: nucleoplasm
Molecular Function: chromatin binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity
Biological Process: apoptosis; cell proliferation; establishment and/or maintenance of chromatin architecture; heart development; negative regulation of transcription from RNA polymerase II promoter; neural crest cell migration; neural tube closure; neuron fate commitment; organ morphogenesis; pigmentation during development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of somitogenesis; sensory perception of sound; spinal cord association neuron differentiation; transcription from RNA polymerase II promoter
Disease: Craniofacial-deafness-hand Syndrome; Rhabdomyosarcoma 2; Waardenburg Syndrome, Type 1; Waardenburg Syndrome, Type 3
Research Articles on PAX3
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Product Notes
The PAX3 pax3 (Catalog #AAA565067) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Pax3 monoclonal antibody (C2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Pax3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) (PS), Western Blot (WB). Western Blot (1ug/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Detects a band of ~53kDa by Western blot. Researchers should empirically determine the suitability of the PAX3 pax3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pax3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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