Dilution Information
Rabbit anti-Human pan-TRK Monoclonal Antibody | anti-pan-TRK antibody
pan-TRK (RM423)
Reactivity
Human
Synonyms
pan-TRK; Monoclonal Antibody; pan-TRK (RM423); NTRK1; TRKA; Ntrk2; NTRK3; trkB; TRKC; p- Trk; sp Trk; pTrk; anti NTRK1; anti NTRK2; anti NTRK3; anti p Trk; anti p-Trk; anti Pan Trk; anti pTrk; anti TRKA; anti TRKB; anti TRKC; anti-NTRK1; anti-NTRK2; anti-NTRK3; anti-p Trk; anti-p-Trk; anti-Pan Trk; anti-pTrk; anti-TRKA; anti-TRKB; anti-TRKC; Pan Trk; Oncogene TRK; p140 TrkA; TRK; Trk A; TRK1; TRK1 transforming tyrosine kinase protein; Tyrosine kinase receptor A; High affinity nerve growth factor receptor precursor; Neurotrophic tyrosine kinase receptor type 2; Neurotrophic tyrosine kinase receptor type 3; Tkr; Tkrb; Trk B; Trk C; TrkB tyrosine kinase; TrkC tyrosine kinase; ETS related protein neurotrophic receptor tyrosine kinase fusion protein; ETV6 NTRK3 fusion; GP145 TrkB; tyrosine kinase receptor B; tyrosine kinase receptor C; BDNF tropomyosine receptor kinase B; gp140trk; neurotrophin 3; Ntrk3 tv3; tropomyosin related kinase A; tropomyosin related kinase B; Tyrosine kinase receptor; anti-pan-TRK antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM423
Form/Format
Paraffin, Frozen
pan-TRK is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
pan-TRK is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the C-terminus of the human TRK protein.
Control
Brain, Lung Neuroendocrine Cancer
Localization
Nuclear, Cytoplasmic
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(pan-TRK Antibody Immunohistochemistry on an FFPE Diffuse Gastric Carcinoma Tissue)
Immunohistochemistry (IHC)
(pan-TRK Antibody Immunohistochemistry on an FFPE Diffuse Gastric Carcinoma Tissue)
Related Product Information for anti-pan-TRK antibody
Neurotrophic tyrosine kinase (NTRK) proto-oncogene family codes for proteins Trk A, Trk B, and Trk C, which participate in pathways of neuron cell growth, differentiation, signaling, and survival. The transmembrane neurotrophic receptors are activated by neurotrophins (Nerve Growth Factor, Brain-Derived Growth Factor, and neurotrophins 3/4/5) and in turn the TRKs activate MAPK, AKT, and Phospholipase C pathways. Non-fusion alterations in NTRK have been found in 14% of tested cancers. panTRK staining can be cytoplasmic, nuclear (as in NTRK-ETV6 and NTRK-LMNA fusions), or membranous (in NTRK-TMP3/4) depending on the fusion pair.
NTRK fusions result in NTRK3-ETV6 pairs in 90% of cases, most commonly found in Carcinomas and Sarcomas of the Mammary and Salivary Secretory Glands. NTRK gene fusions are also found in Brain primary tumors and metastases, Lung, Breast, Papillary Thyroid Carcinoma, Colorectal and Pancreatic cancer. NTRK mesenchymal tumors have multiple morphological features and coexpression of S100, CD34, and panTRK.
NTRK fusions result in NTRK3-ETV6 pairs in 90% of cases, most commonly found in Carcinomas and Sarcomas of the Mammary and Salivary Secretory Glands. NTRK gene fusions are also found in Brain primary tumors and metastases, Lung, Breast, Papillary Thyroid Carcinoma, Colorectal and Pancreatic cancer. NTRK mesenchymal tumors have multiple morphological features and coexpression of S100, CD34, and panTRK.
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Product Notes
The pan-TRK (Catalog #AAA370508) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The pan-TRK (RM423) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "pan-TRK, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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