Western Blot (WB)
(Western Blot analysis of pig retina tissue using NR2E3 Monoclonal Antibody at dilution of 1:1000.)
Mouse anti-Human NR2E3 Monoclonal Antibody | anti-NR2E3 antibody
NR2E3 Monoclonal Antibody
Western Blot (WB)
(Western Blot analysis of pig retina tissue using NR2E3 Monoclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of pig retina tissue using NR2E3 Monoclonal Antibody at dilution of 1:1000.)
NCBI and Uniprot Product Information
Observed Molecular Weight: 50kDa
NCBI Description
This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
NR2E3: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS). ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 15q23
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process: eye photoreceptor cell development; intracellular receptor signaling pathway; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; phototransduction; positive regulation of rhodopsin gene expression; positive regulation of transcription from RNA polymerase II promoter; retina development in camera-type eye; signal transduction; steroid hormone mediated signaling; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; visual perception
Disease: Enhanced S-cone Syndrome; Retinitis Pigmentosa 37
Research Articles on NR2E3
Similar Products
Product Notes
The NR2E3 nr2e3 (Catalog #AAA2549107) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NR2E3 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NR2E3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the NR2E3 nr2e3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NR2E3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
