Mouse Notch1 Monoclonal Antibody | anti-NOTCH1 antibody

Notch1 Monoclonal Antibody

Cat. Num. AAA190928

• Gene Names: NOTCH1; hN1; AOS5; TAN1; AOVD1
• Applications: Immunoblot, Western Blot
• Synonyms: Notch1; Monoclonal Antibody; Notch1 Monoclonal Antibody; Anti-Notch1; anti-NOTCH1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: This antibody recognizes mouse and rat Notch1. It does not cross-react with Notch2 or Notch3.
• Sequence Length: 141

• Applicable Applications for anti-NOTCH1 antibody: Immunoblot (IB)
• Application Notes: Immunoblotting: Use at 1ug/ml. Bands of >270kDa, ~120kDa, and smaller fragments (due to proteolysis) are detected.
• Antigen: Fusion protein corresponding to aa 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 (accession no. Q01705).
• Positive Control: Rat brain lysate
• Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.

Related Product Information for anti-NOTCH1 antibody

Members of the Notch trans-membrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. The Notch signaling network is an intercellular signaling pathway that regulates interactions between physically adjacent cells. The Notch1 protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. There is evidence that activated Notch 1 and Notch 3 promot differentiation of progenitor cells into astroglia. Notch 1, activated before birth, induces radial glia differentiation,but postnatally induces the differentiation into astrocytes.

Product Categories/Family for anti-NOTCH1 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 48146559
• NCBI GeneID: 4851
• UniProt Accession #: Q6IAD4; P46531
• Molecular Weight: 14,768 Da
• NCBI Official Full Name: NOTCH1
• NCBI Official Synonym Full Names: notch 1
• NCBI Official Symbol: NOTCH1
• NCBI Official Synonym Symbols: hN1; AOS5; TAN1; AOVD1
• NCBI Protein Information: neurogenic locus notch homolog protein 1
• UniProt Protein Name: NOTCH1 protein
• Protein Family: Neurogenic locus notch homolog protein
• UniProt Gene Name: NOTCH1
• UniProt Entry Name: Q6IAD4_HUMAN

NCBI Description

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]