Mouse anti-Human Non-Metastatic Cells 2 Monoclonal Antibody | anti-NME2 antibody

Mouse Anti Human Non-Metastatic Cells 2

Cat. Num. AAA147001

• Gene Names: NME2; PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Synonyms: Non-Metastatic Cells 2; Monoclonal Antibody; Mouse Anti Human Non-Metastatic Cells 2; Nucleoside diphosphate kinase B; NDPK-B; NDPKB; NM23-H2; NM23B; EC 2.7.4.6; NDP kinase B; C-myc purine-binding transcription factor PUF; NDK B; NME2; puf; MGC111212; NME2 Antibody; Mouse Anti Human; anti-NME2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b heavy chain and kappa light chain
• Clone Number: PAT5F4AT
• Purity/Purification: Purified from mouse ascitic fluids by protein-A affinity chromatography
• Form/Format: Sterile filtered colorless solution; 1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide
• Sequence Length: 152

• Applicable Applications for anti-NME2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Anti-human NME2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NME2 amino acids 1-152 purified from E Coli
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at-20 degree C.; Prevent freeze thaw cycles

Related Product Information for anti-NME2 antibody

NME2 takes an important part in the synthesis of nucleoside triphosphates other than ATP. NME2 negatively controls Rho activity by interacting with AKAP13/LBC. NME2 acts as a transcriptional activator of the MYC gene. NME2 binds DNA non-specifically. NME2 is a heterodimeric enzyme functioning as a nucleoside diphosphate kinase. NME1 and NME2 contain 152 amino acids, A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases participate in the synthesis of nucleoside triphosphates, and NM23 is involved in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways.

Product Categories/Family for anti-NME2 antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme; NME2 Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 12803317
• NCBI GeneID: 4831
• Molecular Weight: 30,137 Da
• NCBI Official Full Name: Non-metastatic cells 2, protein (NM23B) expressed in
• NCBI Official Synonym Full Names: NME/NM23 nucleoside diphosphate kinase 2
• NCBI Official Symbol: NME2
• NCBI Official Synonym Symbols: PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
• NCBI Protein Information: nucleoside diphosphate kinase B
• UniProt Protein Name: Nucleoside diphosphate kinase B
• UniProt Gene Name: NME2
• UniProt Synonym Gene Names: NM23B; NDK B; NDP kinase B

NCBI Description

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

Uniprot Description

Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.