Mouse Nerve Growth Factor, Bovine Monoclonal Antibody | anti-NTF3 antibody

Nerve Growth Factor, Bovine (NGF)

Cat. Num. AAA631741

• Gene Names: NTF3; NT3; HDNF; NGF2; NGF-2; MGC129711
• Reactivity: Bovine
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Nerve Growth Factor; Bovine; Monoclonal Antibody; Bovine (NGF); Anti -Nerve Growth Factor; anti-NTF3 antibody

• Host: Mouse
• Reactivity: Bovine
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 1.A.2
• Specificity: Recognizes bovine NGF by Western analysis.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in 0.1M Tris HCl, pH 7.5.

• Applicable Applications for anti-NTF3 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Puri?ed bovine NGF
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-NTF3 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 287795
• NCBI GeneID: 4908
• UniProt Accession #: P20783; Q6FH50
• Molecular Weight: 29,355 Da
• NCBI Official Full Name: nerve growth factor
• NCBI Official Synonym Full Names: neurotrophin 3
• NCBI Official Symbol: NTF3
• NCBI Official Synonym Symbols: NT3; HDNF; NGF2; NGF-2; MGC129711
• NCBI Protein Information: neurotrophin-3; NT-3; OTTHUMP00000239132; OTTHUMP00000239133; neurotrophic factor; nerve growth factor 2
• UniProt Protein Name: Neurotrophin-3
• Protein Family: Neurotrophin
• UniProt Gene Name: NTF3
• UniProt Entry Name: NTF3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq]

Uniprot Description

NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; receptor binding; chemoattractant activity

Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; regulation of neuron differentiation; activation of MAPK activity; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; cell-cell signaling; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; smooth muscle cell differentiation; nerve development; positive regulation of transcription from RNA polymerase II promoter; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; positive regulation of cell migration