Rabbit anti-Human MyD88 Monoclonal Antibody | anti-MyD88 antibody

Anti-MyD88 Monoclonal Antibody

Cat. Num. AAA1751901

• Gene Names: MYD88; MYD88D
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Affinity-Chromatography
• Synonyms: MyD88; Monoclonal Antibody; Anti-MyD88 Monoclonal Antibody; anti-MyD88 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Affinity-Chromatography
• Form/Format: Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 251

• Applicable Applications for anti-MyD88 antibody: Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: WB: 1:1000-1:2000; IHC: 1:50-1:200; ICC/IF: 1:50-1:200; FC/FACS: 1:100
• Immunogen: A synthesized peptide derived from human MyD88 Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF- Kappa B and subsequent regulation of immune and inflammatory genes.
• Preparation and Storage: Store at 4 degree C short term. Store at -20 degree C long term; Avoid freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescent analysis of A549 cells, using MyD88 Antibody.)

Related Product Information for anti-MyD88 antibody

Rabbit IgG Monoclonal antibody for Q99836 detection. Tested positive for WB IHC IF/IF FC in Human

NCBI and Uniprot Product Information

• NCBI GI #: 289546500
• NCBI GeneID: 4615
• NCBI Accession #: NP_001166037.1
• NCBI GenBank Nucleotide #: NM_001172566.1
• UniProt Accession #: Q99836; P78397; Q53XS7; B4DKH8; B4DKU4; B4DQ60; B4DQ72; J3KPU4; J3KQ87; J3KQJ6
• Molecular Weight: 28,280 Da
• NCBI Official Full Name: myeloid differentiation primary response protein MyD88 isoform 5
• NCBI Official Synonym Full Names: MYD88, innate immune signal transduction adaptor
• NCBI Official Symbol: MYD88
• NCBI Official Synonym Symbols: MYD88D
• NCBI Protein Information: myeloid differentiation primary response protein MyD88
• UniProt Protein Name: Myeloid differentiation primary response protein MyD88
• Protein Family: Myeloid differentiation primary response protein
• UniProt Gene Name: MYD88

NCBI Description

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Description

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine ().