Mouse anti-Human MVP/VAULT1 Monoclonal Antibody | anti-MVP/VAULT1 antibody

Anti-MVP/VAULT1 Antibody (clone 2H3-1A6)

Cat. Num. AAA2400634

• Gene Names: MVP; LRP; VAULT1
• Reactivity: Human
• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Purified from ascites by Protein A
• Synonyms: MVP/VAULT1; Monoclonal Antibody; Anti-MVP/VAULT1 Antibody (clone 2H3-1A6); Rabbit Polyclonal to Human MVP/VAULT1; MVP; Major vault protein; VAULT1; LRP; anti-MVP/VAULT1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a, k
• Clone Number: 2H3-1A6
• Specificity: Human MVP
• Purity/Purification: Purified from ascites by Protein A
• Form/Format: PBS, pH 7.4.
• Sequence Length: 893

• Applicable Applications for anti-MVP/VAULT1 antibody: ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IF: 10 ug/ml; IHC-P: 3-5 ug/ml; WB: 1:500-1:1000
• Immunogen: MVP (AAH15623, 1 a.a. ~ 894 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C or lower.; Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-MVP antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Immunohistochemistry (WB)

(Anti-MVP antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of monoclonal antibody to MVP on HeLa cell. [antibody concentration 10 ug/ml])

Western Blot (WB)

(Antibody Western blot of MVP expression in HeLa NE.)

ELISA (EIA)

(Detection limit for recombinant GST tagged MVP is approximately 1 ng/ml as a capture antibody.)

Related Product Information for anti-MVP/VAULT1 antibody

MVP/VAULT1 is the major component of the vault complex. Vaults aremulti-subunit ribonucleoprotein structures that may be involved innucleo-cytoplasmic transport. the encoded protein may play a role inmultiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. the encoded protein also plays a role in multidrug resistance, and expression of this genemay be a prognostic marker for several types of cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 19913410
• NCBI GeneID: 9961
• NCBI Accession #: NP_059447.2
• NCBI GenBank Nucleotide #: NM_017458.3
• UniProt Accession #: Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1
• Molecular Weight: 99,327 Da
• NCBI Official Full Name: major vault protein isoform 1
• NCBI Official Synonym Full Names: major vault protein
• NCBI Official Symbol: MVP
• NCBI Official Synonym Symbols: LRP; VAULT1
• NCBI Protein Information: major vault protein
• UniProt Protein Name: Major vault protein
• UniProt Gene Name: MVP
• UniProt Synonym Gene Names: LRP; MVP

NCBI Description

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Description

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.