Mouse monoclonal to human 85 kDa LRP, Clone 8B8 Monoclonal Antibody | anti-LRP1 antibody

Mouse monoclonal to human 85 kDa LRP, Clone 8B8

Cat. Num. AAA135089

• Gene Names: LRP1; APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
• Reactivity: Human, rabbit
• Applications: Flow Cytometry, Immunohistochemistry, Immunofluorescence, Western Blot
• Purity: IgG fraction
• Synonyms: Mouse monoclonal to human 85 kDa LRP; Clone 8B8; Monoclonal Antibody; anti-LRP1 antibody

• Host: Host: Mouse; Source: Mouse ascites
• Reactivity: Human, rabbit
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8B8
• Purity/Purification: IgG fraction
• Form/Format: Frozen liquid
• Concentration: 5.0 mg/ml (varies by lot)
• Sequence Length: 4544

• Applicable Applications for anti-LRP1 antibody: Flow Cytometry (FC), Immunohistochemistry (IHC) Paraffin, Immunoflurescence (IF), Western Blot (WB)
• Immunogen: Full length native protein (purified) (Human).
• Target Information: Recognises the 85kDa cleaved fragment of Low Density LRP (extracellular domain).
• Target Molecular Weight: 85000
• Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
• Extinction Coefficient: 1.36
• Preparation and Storage: Store at -70 degree C. Shelf Life: 5 years from delivery

Related Product Information for anti-LRP1 antibody

Monoclonal antibody to human 85 kDa light chain of LRP. Cross-reacts with rabbit LRP. Use WI-38 fibroblast as positive control and human umbilical vein endothelial cells (HUVEC) as negative control. Purified by immobilized Protein A. IgG1 class.

Product Categories/Family for anti-LRP1 antibody

Receptor Associated Protein (RAP); Monoclonal Antibodies to Human LRP

NCBI and Uniprot Product Information

• NCBI GI #: 126012562
• NCBI GeneID: 4035
• NCBI Accession #: NP_002323.2
• NCBI GenBank Nucleotide #: NM_002332.2
• UniProt Accession #: Q07954; Q2PP12; Q8IVG8
• Molecular Weight: 160,000
• NCBI Official Full Name: prolow-density lipoprotein receptor-related protein 1
• NCBI Official Synonym Full Names: low density lipoprotein receptor-related protein 1
• NCBI Official Symbol: LRP1
• NCBI Official Synonym Symbols: APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
• NCBI Protein Information: prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor
• UniProt Protein Name: Prolow-density lipoprotein receptor-related protein 1
• Protein Family: Exosome complex protein
• UniProt Gene Name: LRP1
• UniProt Synonym Gene Names: A2MR; APR; LRP-1; A2MR; APOER; LRP-85; LRP-515; LRPICD
• UniProt Entry Name: LRP1_HUMAN

NCBI Description

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]

Uniprot Description

LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; integral to plasma membrane; lysosomal membrane; dendrite; cytoplasm; nucleolus; plasma membrane; coated pit; receptor complex; endosome

Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; receptor activity; calcium ion binding

Biological Process: receptor-mediated endocytosis; phototransduction, visible light; cholesterol metabolic process; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; retinoid metabolic process; regulation of cholesterol transport; apoptotic cell clearance; aging