Immunofluorescence (IF)
(MMSET / WHSC1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with MMSET / WHSC1 antibody at a 0.5 ug/ml dilution.)
Mouse anti-Human MMSET/WHSC1 Monoclonal Antibody | anti-MMSET/WHSC1 antibody
MMSET/WHSC1 antibody (mAb)(Clone 29D1)
Gene Names
WHSC1; WHS; NSD2; TRX5; MMSET; REIIBP
Reactivity
Human
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Purity
Protein G Chromatography
Synonyms
MMSET/WHSC1; Monoclonal Antibody; MMSET/WHSC1 antibody (mAb)(Clone 29D1); WHS; NSD2; TRX5; REIIBP; anti-MMSET/WHSC1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
29D1
Purity/Purification
Protein G Chromatography
Form/Format
Purified IgG in 70mM Tris (pH8), 105mM NaCl, 31mM glycine, 0.07mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Concentration
1ug/ul (varies by lot)
Applicable Applications for anti-MMSET/WHSC1 antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes
Applications Validated:
ICC/IF: 0.5ug/ml dilution
ICC/IF: 0.5ug/ml dilution
Immunogen
This MMSET/WHSC1 antibody was raised against a recombinant protein corresponding to amino acids 1-647 of human MMSET-I.
Preparation and Storage
Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20 degree C for up to 2 years. Keep all reagents on ice when not in storage.1ug/ul
Immunofluorescence (IF)
(MMSET / WHSC1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with MMSET / WHSC1 antibody at a 0.5 ug/ml dilution.)
Immunofluorescence (IF)
(MMSET / WHSC1 antibody (mAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with MMSET / WHSC1 antibody at a 0.5 ug/ml dilution.)
Related Product Information for anti-MMSET/WHSC1 antibody
Short Description: Our MMSET/WHSC1 antibody (mAb)(Clone 29D1) was raised in a Mouse host. It has been validated for use in Immunocytochemistry, Immunofluorescence and Western blot; it has been shown to react with Human samples.
Background: MMSET (Multiple Myeloma SET domain-containing protein)/WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1; also known as NSD2, Nuclear Receptor binding SET domain protein 2; TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The MMSET/WHSC1 gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to MMSET/WHSC1 gene being aberrantly placed under the control of the IgH intronic u enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in MMSET/WHSC1 expression in a myeloma cell line suppressed its growth, suggesting a role for MMSET in maintaining the transformed state.
Background: MMSET (Multiple Myeloma SET domain-containing protein)/WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1; also known as NSD2, Nuclear Receptor binding SET domain protein 2; TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The MMSET/WHSC1 gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to MMSET/WHSC1 gene being aberrantly placed under the control of the IgH intronic u enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in MMSET/WHSC1 expression in a myeloma cell line suppressed its growth, suggesting a role for MMSET in maintaining the transformed state.
Product Categories/Family for anti-MMSET/WHSC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30,199 Da
NCBI Official Full Name
histone-lysine N-methyltransferase NSD2 isoform 1
NCBI Official Synonym Full Names
Wolf-Hirschhorn syndrome candidate 1
NCBI Official Symbol
WHSC1
NCBI Official Synonym Symbols
WHS; NSD2; TRX5; MMSET; REIIBP
NCBI Protein Information
histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; multiple myeloma SET domain containing protein type III; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; trithorax/ash1-related p
UniProt Protein Name
Histone-lysine N-methyltransferase NSD2
UniProt Gene Name
WHSC1
UniProt Synonym Gene Names
KIAA1090; MMSET; NSD2; TRX5; MMSET; NSD2; WHSC1
UniProt Entry Name
NSD2_HUMAN
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Product Notes
The MMSET/WHSC1 whsc1 (Catalog #AAA388617) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MMSET/WHSC1 antibody (mAb)(Clone 29D1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MMSET/WHSC1 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Applications Validated: ICC/IF: 0.5ug/ml dilution. Researchers should empirically determine the suitability of the MMSET/WHSC1 whsc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMSET/WHSC1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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