Mouse MMS19 Monoclonal Antibody | anti-MMS19 antibody

MMS19 Mouse Monoclonal

Cat. Num. AAA7601482

• Gene Names: MMS19; MET18; MMS19L; hMMS19
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: MMS19; Monoclonal Antibody; MMS19 Mouse Monoclonal; anti-MMS19 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 1030

• Applicable Applications for anti-MMS19 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Immunogen: MMS19 nucleotide excision repair homolog (S. cerevisiae)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human cervical cancer using MBS7601482 (MMS19 antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7601482 (MMS19 Antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 574957204
• NCBI GeneID: 64210
• NCBI Accession #: NP_001276334.1
• NCBI GenBank Nucleotide #: NM_001289405.1
• Molecular Weight: 108,380 Da
• NCBI Official Full Name: MMS19 nucleotide excision repair protein homolog isoform 1
• NCBI Official Synonym Full Names: MMS19 homolog, cytosolic iron-sulfur assembly component
• NCBI Official Symbol: MMS19
• NCBI Official Synonym Symbols: MET18; MMS19L; hMMS19
• NCBI Protein Information: MMS19 nucleotide excision repair protein homolog
• UniProt Protein Name: MMS19 nucleotide excision repair protein homolog
• Protein Family: MMS19 nucleotide excision repair protein
• UniProt Gene Name: MMS19
• UniProt Synonym Gene Names: MMS19L; hMMS19
• UniProt Entry Name: MMS19_HUMAN

Uniprot Description

MMS19: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Belongs to the MET18/MMS19 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q24-q25

Cellular Component: cytoplasm; holo TFIIH complex; membrane; nucleoplasm; nucleus; spindle

Molecular Function: enzyme binding; estrogen receptor binding; protein binding; protein binding, bridging; receptor signaling complex scaffold activity; transcription coactivator activity

Biological Process: chromosome segregation; DNA metabolic process; DNA repair; iron-sulfur cluster assembly; nucleotide-excision repair; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to hormone stimulus; transcription, DNA-dependent; two-component signal transduction system (phosphorelay)