Dilution Information
Mouse MLH1 Monoclonal Antibody | anti-MLH1 antibody
MLH1
Gene Names
Mlh1; CG11482; DmelCG11482; dmlh-1; dmlh1
Reactivity
Human, Rat, Mouse
Synonyms
MLH1; Monoclonal Antibody; anti-MLH1 antibody
Host
Mouse
Reactivity
Human, Rat, Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
G168-728
Form/Format
Anti-MLH1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Colon Mucosa, Colon Carcinoma
Localization
Nuclear
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Related Product Information for anti-MLH1 antibody
MLH1 is a mismatch repair gene of around 87 kDa, commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. In a high proportion of patients with microsatellite instability (MSI-H), the MLH1 protein is typically deficient. This protein deficiency is linked to the autosomal dominant condition of Hereditary Non-Polyposis Colon Cancer. The anti-MLH1antibody is useful in screening patients and families for this condition. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite stable counterparts.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
Mlh1
NCBI Official Symbol
Mlh1
NCBI Official Synonym Symbols
CG11482; DmelCG11482; dmlh-1; dmlh1
NCBI Protein Information
CG11482 gene product from transcript CG11482-RA; Mlh1; CG11482-PA; Mlh1-PA
Protein Family
Similar Products
Product Notes
The MLH1 (Catalog #AAA370089) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MLH1 reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "MLH1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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