Mouse MEK6 Monoclonal Antibody | anti-MEK6 antibody

MEK6 antibody

• Gene Names: MAP2K6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
• Applications: ELISA, Immunoprecipitation
• Purity: MEK6 antibody was purified by ammonium sulfate precipitation
• Synonyms: MEK6; Monoclonal Antibody; MEK6 antibody; Monoclonal MEK6; Anti-MEK6; MAP2K6; mitogen-activated protein kinase kinase 6; BOS_19573; dual specificity mitogen-activated protein kinase kinase 6; map2k3; MAPK/ERK kinase 6; MAP kinase kinase 6; mapkk6; MAPKK 6; MEK 6; mitogen-activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; MKK3; Mkk6; PRKMK6; protein kinase; mitogen activated; kinase 6; mitogen-activated; kinase 6 (MAP kinase kinase 6); RP23-162E10.1; SAPKK3; SAPKK-3; SAPK kinase 3; stress-activated protein kinase kinase 3; zMKK3; anti-MEK6 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: AF8B6
• Purity/Purification: MEK6 antibody was purified by ammonium sulfate precipitation
• Form/Format: Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 334

• Applicable Applications for anti-MEK6 antibody: ELISA (EIA), Immunoprecipitation (IP)
• Application Notes: IP: 2 ul
• Biological Significance: MEK6 encodes a 334-amino acid protein with 82% identity to MKK3. MEK6 is highly expressed in skeletal muscle like many other members of this family, but in contrast to MKK3 its expression in leukocytes is very low. The human MEKs (MEK1, MEK2, MEK3) show remarkably different activity toward ERKl and ERK2. MEK2 is the most active ERK activator. MEK3 is inactive toward ERKl or ERK2. MEK3, MEK4, and MEK6 phosphorylate and activate p38 MAP kinase. The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and environmental stress. Transcription factors such as ATF2 and Elk-1 are targets of the p38 MAP kinase signal transduction pathway.
• Cross-Reactivity: Human
• Immunogen: MEK6 antibody was raised in Mouse using a recombinant human protein purified from E Coli (His-MEK6) as the immunogen
• Preparation and Storage: Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

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Related Product Information for anti-MEK6 antibody

Mouse monoclonal MEK6 antibody

Product Categories/Family for anti-MEK6 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 1314477
• NCBI GeneID: 5608
• UniProt Accession #: P52564
• Molecular Weight: 31,339 Da
• NCBI Official Full Name: MAP kinase kinase MEK6
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase 6
• NCBI Official Symbol: MAP2K6
• NCBI Official Synonym Symbols: MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3
• NCBI Protein Information: dual specificity mitogen-activated protein kinase kinase 6
• UniProt Protein Name: Dual specificity mitogen-activated protein kinase kinase 6
• UniProt Gene Name: MAP2K6
• UniProt Synonym Gene Names: MEK6; MKK6; PRKMK6; SKK3; MAP kinase kinase 6; MAPKK 6; MEK 6; SAPK kinase 3; SAPKK-3; SAPKK3
• UniProt Entry Name: MP2K6_HUMAN

NCBI Description

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

MKK6: a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. Three alternatively spliced isoforms have been reported.

Protein type: Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); Kinase, protein; EC 2.7.12.2; STE group; STE7 family

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: nucleoplasm; cytoskeleton; cytosol

Molecular Function: MAP kinase kinase activity; protein binding; protein-tyrosine kinase activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; DNA damage induced protein phosphorylation; activation of MAPK activity; apoptosis; positive regulation of apoptosis; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; ovulation cycle process; regulation of transcription, DNA-dependent; cell cycle arrest; toll-like receptor 4 signaling pathway; cardiac muscle contraction; response to drug; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; positive regulation of prostaglandin secretion; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of nitric-oxide synthase biosynthetic process