Mouse anti-Human MDR3 P-glycoprotein Monoclonal Antibody | anti-ABCB4 antibody
MDR3 P-glycoprotein (ATP-binding cassette, sub-family B (MDR/TAP), member 4, ABCB4, PGY3)
Supernatant
Supernatant
NCBI and Uniprot Product Information
NCBI Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
Uniprot Description
ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.
Protein type: Membrane protein, integral; Hydrolase; Membrane protein, multi-pass; Transporter; Transporter, ABC family; EC 3.6.3.44
Chromosomal Location of Human Ortholog: 7q21.1
Cellular Component: intercellular canaliculus; membrane; integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding; xenobiotic-transporting ATPase activity
Biological Process: response to drug; transport; xenobiotic transport; multidrug transport; cellular lipid metabolic process; lipid metabolic process; transmembrane transport
Disease: Gallbladder Disease 1; Cholestasis, Progressive Familial Intrahepatic, 3; Cholestasis, Intrahepatic, Of Pregnancy 3
Research Articles on ABCB4
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Product Notes
The ABCB4 abcb4 (Catalog #AAA602543) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MDR3 P-glycoprotein (ATP-binding cassette, sub-family B (MDR/TAP), member 4, ABCB4, PGY3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MDR3 P-glycoprotein can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Suitable for use in Immunocytochemistry, Immunohistochemistry and Western Blot.,, Recommended Dilution:, Immunocytochemistry: 1:20-1:50 for acetone-fixed cytospin preparations., Immunohistochemistry (frozen sections): 1:20 for acetone fixed sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Not recommended for paraffin sections., Optimal dilutions to be determined by researcher. Researchers should empirically determine the suitability of the ABCB4 abcb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MDR3 P-glycoprotein, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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