Mouse anti-Human MALT1 Monoclonal Antibody | anti-MALT1 antibody

MALT1 (Caspase-like Protein, MALT lymphoma-Associated translocation, MLT1, Mucosa-Associated lymphoid tissue lymphoma translocation Protein 1, Paracaspase) (Biotin)

Cat. Num. AAA6124344

• Gene Names: MALT1; MLT; MLT1
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: MALT1; Monoclonal Antibody; MALT1 (Caspase-like Protein; MALT lymphoma-Associated translocation; MLT1; Mucosa-Associated lymphoid tissue lymphoma translocation Protein 1; Paracaspase) (Biotin); Caspase-like Protein; Paracaspase; anti-MALT1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: SPM578
• Specificity: Recognizes human MALT1.
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Biotin.

• Applicable Applications for anti-MALT1 antibody: ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IP: 1-2ug/500ug protein lysate; FC/FACS: 0.5-1ug/million cells; IHC: 0.5-1ug/ml for 30 minutes at RT; IF: 1-2ug/ml; WB: 0.5-1ug/ml; Applications are based on unconjugated antibody.
• Immunogen: Human MALT1 recombinant fragment (aa701-808). Cellular Localization: Cytoplasmic
• Conjugate: Biotin
• Positive Control: Jurkat, Daudi or HeLa cells, or lymphoma.
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Formalin-fixed, paraffin-embedded tonsil stained with MALT1 MAb (SPM578))

Product Categories/Family for anti-MALT1 antibody

Antibodies; Apoptosis

References

1. Ye H et. al. J Pathol 2005; 205: 293-301.

NCBI and Uniprot Product Information

• NCBI GI #: 5803078
• NCBI GeneID: 10892
• NCBI Accession #: NP_006776.1
• NCBI GenBank Nucleotide #: NM_006785.2
• UniProt Accession #: Q9UDY8; Q9NTB7; Q9ULX4
• Molecular Weight: 92,272 Da
• NCBI Official Full Name: mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a
• NCBI Official Synonym Full Names: mucosa associated lymphoid tissue lymphoma translocation gene 1
• NCBI Official Symbol: MALT1
• NCBI Official Synonym Symbols: MLT; MLT1
• NCBI Protein Information: mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation
• UniProt Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1
• Protein Family: Mucosa-associated lymphoid tissue lymphoma translocation protein
• UniProt Gene Name: MALT1
• UniProt Synonym Gene Names: MLT
• UniProt Entry Name: MALT1_HUMAN

NCBI Description

This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; Ligase; Adaptor/scaffold; EC 3.4.22.-; Protease; Ubiquitin conjugating system; Apoptosis

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: CBM complex; protein complex; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; nucleus; cytosol

Molecular Function: peptidase activity; protein binding; signal transducer activity; protein self-association; protease binding; cysteine-type endopeptidase activity; ubiquitin-protein ligase activity; kinase activator activity

Biological Process: response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; nuclear export; activation of NF-kappaB-inducing kinase; positive regulation of T cell cytokine production; protein ubiquitination; defense response; proteolysis; T cell receptor signaling pathway; protein oligomerization; activation of NF-kappaB transcription factor; T cell proliferation; regulation of apoptosis; B-1 B cell differentiation; positive regulation of protein ubiquitination; response to molecule of bacterial origin; regulation of T cell receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of T cell activation; negative regulation of apoptosis

Disease: Immunodeficiency 12