Rat Macrophage Scavenger Receptor Type I Monoclonal Antibody | anti-MSR1 antibody

Macrophage Scavenger Receptor Type I (MSR1, CD204, Macrophage Acetylated LDL Receptor I and II, Macrophage Scavenger Receptor Types I and II, phSR1, Scavenger Receptor Class A Member 1, SCARA1, Scavenger Receptor Type A, SRA, Scvr) (MaxLight 550)

Cat. Num. AAA6255098

• Gene Names: Msr1; MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
• Reactivity: Mouse, Porcine
• Applications: Flow Cytometry, Functional Assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Purified by protein G affinity chromatography from tissue culture supernatant.
• Synonyms: Macrophage Scavenger Receptor Type I; Monoclonal Antibody; Macrophage Scavenger Receptor Type I (MSR1; CD204; Macrophage Acetylated LDL Receptor I and II; Macrophage Scavenger Receptor Types I and II; phSR1; Scavenger Receptor Class A Member 1; SCARA1; Scavenger Receptor Type A; SRA; Scvr) (MaxLight 550); anti-MSR1 antibody

• Host: Rat
• Reactivity: Mouse, Porcine
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 10B1015
• Specificity: Recognizes mouse Macrophage Scavenger Receptor Type I and II. Reacts with an epitope within Macrophage Scavenger Receptor Type I that is polymorphic in the Macrophage Scavenger Receptor Type I from C57BL/6 mice and is therefore unsuitable for use with the C57BL/6 mouse strain. Species Crossreactivity: channel catfish, porcine
• Purity/Purification: Purified by protein G affinity chromatography from tissue culture supernatant.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight550.

• Applicable Applications for anti-MSR1 antibody: Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Immunogen: Raw 264 cell line.
• Conjugate: MaxLight550
• Preparation and Storage: Store at 4 degree C. Do Not Freeze.

Testing Data

(Staining of J774 cell line with M1210-04C.)

Product Categories/Family for anti-MSR1 antibody

Antibodies; Receptors; Scavenger

References

1. Fraser, I.P. et al. (1993) Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature 364: 343-346. 2. de Villiers, W.J.S. et al. (1994) Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function J. Exp. Med. 180: 705-709. 3. Hughes, D.A.et al. (1995) Murine Macrophage Scavenger Receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs. Eur. J. Immunol. 25: 466-473. 4. Bell, M.D.et al. (1994) Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS. J. Neurocytol. 23: 605-613. 5. Hughes, D.A. et al. (1994) Murine Macrophage Scavenger Receptor: Adhesion function and Expression. Imm. Letts. 43: 7-14. 6. Rosen, H. and Hughes, D.A. (1995) Assays of Myeloid Cell Function: Migration and adhesion in vivo. Weir Handbook of Experimental Immunology. London, Blackwell Scientific Publications. 5th, ed. In Press. 7. Daugherty, A. et al. (2000) Polymorphism of class A scavenger receptors in C57BL/6 mice. J. Lipid Res 41: 1568 - 1577. 8. Moldenhauer, L.M. et al. (2010) GM-CSF Is an Essential Regulator of T Cell Activation Competence in Uterine Dendritic Cells during Early Pregnancy in Mice. J Immunol. 185: 7085-7096. 9. Luechtenborg, B. et al. (2008) Function of scavenger receptor class A type I/II is not important for smooth muscle foam cell formation. Eur J Cell Biol. 87: 91-9. 10. Sever-Chroneos, Z. et al. (2011) Surfactant Protein A (SP-A)-mediated Clearance of Staphylococcus aureus Involves Binding of SP-A to the Staphylococcal Adhesin Eap and the Macrophage Receptors SP-A Receptor 210 and Scavenger Receptor Class A. J Biol Chem. 286: 4854-70. 11. Yang, C.N. et al. (2011) Mechanism mediating oligomeric Aß clearance by naïve primary microglia. Neurobiol Dis. Jan 8. 12. Hald, A. et al. (2011) MMP9 is protective against lethal inflammatory mass lesions in the mouse colon. Dis Model Mech. 4: 212-27. 13. Swain, S.D. et al. (2011) Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens. Infect Immun. Feb 22. 14. Nikolic, D. et al. (2011) SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation.BMC Immunol. 12: 37. 15. Zaynagetdinov, R. et al. (2011) A Critical Role for Macrophages in Promotion of Urethane-Induced Lung Carcinogenesis. J Immunol. Nov 2. 16. Kaur, H. et al. (2003) Identification of a scavenger receptor homologue on nonspecific cytotoxic cells and evidence for binding to oligodeoxyguanosine. Fish Shellfish Immunol. 15: 169-81. 17. Kaur, H. et al. (2004) Single-base oligodeoxyguanosine-binding proteins on nonspecific cytotoxic cells: identification of a new class of pattern-recognition receptors. Scand J Immunol. 60: 238-48.

NCBI and Uniprot Product Information

• NCBI GI #: 85861254
• NCBI GeneID: 20288
• NCBI Accession #: NP_112472.2
• NCBI GenBank Nucleotide #: NM_031195.2
• UniProt Accession #: P30204; Q923G0; Q9QZ56; E9QNQ5
• Molecular Weight: 38,773 Da
• NCBI Official Full Name: macrophage scavenger receptor types I and II isoform a
• NCBI Official Synonym Full Names: macrophage scavenger receptor 1
• NCBI Official Symbol: Msr1
• NCBI Official Synonym Symbols: MSR; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
• NCBI Protein Information: macrophage scavenger receptor types I and II
• UniProt Protein Name: Macrophage scavenger receptor types I and II
• Protein Family: Macrophage scavenger receptor
• UniProt Gene Name: Msr1
• UniProt Synonym Gene Names: Scvr; SR-A
• UniProt Entry Name: MSRE_MOUSE

Uniprot Description

MSR1: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL. Defects in MSR1 may be a cause of prostate cancer (PC). A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet- ring cell carcinoma and neuroendocrine carcinoma. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families. Defects in MSR1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: collagen; membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; cytosol

Molecular Function: low-density lipoprotein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol transport; lipoprotein transport; endocytosis