Mouse anti-Human Macrophage Inflammatory Protein 1 alpha Monoclonal Antibody | anti-CCL3 antibody
Macrophage Inflammatory Protein 1 alpha (MIP-1 alpha, CCL3, LD78 alpha)
Western Blot: 2-4ug/ml. Used in conjunction with compatiblesecondary reagents the detection limit for recombinant human Macrophage Inflammatory Protein 1 alpha is 1-2ng/lane,under non-reducing conditions.
Neutralization: 5-10ug/ml yields one-half maximal inhibition of the biological activity of human Macrophage Inflammatory Protein 1 alpha (100ng/ml)
Optimal dilution determined by the researcher.
NCBI and Uniprot Product Information
NCBI Description
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.
Uniprot Description
CCL3: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular space; cytoplasm; extracellular region; intracellular; cytosol
Molecular Function: identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; calcium-dependent protein kinase C activity; kinase activity; phospholipase activator activity; protein kinase activity; CCR5 chemokine receptor binding; chemoattractant activity
Biological Process: positive regulation of catalytic activity; negative regulation of osteoclast differentiation; exocytosis; behavior; response to toxin; positive regulation of calcium-mediated signaling; positive regulation of interleukin-1 beta secretion; chemotaxis; protein amino acid phosphorylation; regulation of cell shape; negative regulation of bone mineralization; monocyte chemotaxis; positive chemotaxis; cell-cell signaling; positive regulation of neuron apoptosis; calcium ion transport; protein kinase B signaling cascade; lipopolysaccharide-mediated signaling pathway; inflammatory response; lymphocyte chemotaxis; neutrophil chemotaxis; MAPKKK cascade; calcium-mediated signaling; cytoskeleton organization and biogenesis; positive regulation of tumor necrosis factor production; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; macrophage chemotaxis; cellular calcium ion homeostasis; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; cell activation; eosinophil chemotaxis; eosinophil degranulation; regulation of sensory perception of pain; positive regulation of calcium ion transport; astrocyte cell migration; positive regulation of cell migration; positive regulation of inflammatory response
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Research Articles on CCL3
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Product Notes
The CCL3 ccl3 (Catalog #AAA600391) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Macrophage Inflammatory Protein 1 alpha (MIP-1 alpha, CCL3, LD78 alpha) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Macrophage Inflammatory Protein 1 alpha can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Neutralization, Western Blot (WB). ELISA (Sandwich): 2-4ug/ml using 100ul/well antibodysolution). In conjunction with biotinylated anti-humanMacrophage Inflammatory Protein 1 alpha (1-2ug/ml) as a detection antibody, allows the detection of atleast 2000pg/ml of recombinant human Macrophage Inflammatory Protein 1 alpha. Western Blot: 2-4ug/ml. Used in conjunction with compatiblesecondary reagents the detection limit for recombinant human Macrophage Inflammatory Protein 1 alpha is 1-2ng/lane,under non-reducing conditions. Neutralization: 5-10ug/ml yields one-half maximal inhibition of the biological activity of human Macrophage Inflammatory Protein 1 alpha (100ng/ml) Optimal dilution determined by the researcher. Researchers should empirically determine the suitability of the CCL3 ccl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Macrophage Inflammatory Protein 1 alpha, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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