Western Blot (WB)
(Western blot analysis of CREB3L4 using K562 whole cell lysates)
Rabbit CREB3L4 Polyclonal Antibody | anti-CREB3L4 antibody
CREB3L4 Antibody
Gene Names
CREB3L4; JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
Reactivity
Human, Mouse, Rat
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
CREB3L4; Polyclonal Antibody; CREB3L4 Antibody; 1700012K17Rik; AIbZIP; Androgen induced basic leucine zipper; Androgen induced basic leucine zipper protein; Androgen-induced basic leucine zipper protein; ATCE1; Attaching to CRE like 1; Attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 3 like 4; cAMP responsive element binding protein 4; cAMP responsive element-binding protein 3 like protein 4; cAMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CR3L4_HUMAN; CREB 4; CREB-4; CREB3; CREB4; Cyclic AMP responsive element binding protein 3 like protein 4; Cyclic AMP responsive element binding protein 4; Cyclic AMP-responsive element-binding protein 4; hJAL; JAL; mJAL; Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Tisp40; Tisp40alpha; Tisp40beta; Transcript induced in spermiogenesis protein 40; anti-CREB3L4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CREB3L4 antibody detects endogenous levels of total CREB3L4
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
395
Applicable Applications for anti-CREB3L4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human CREB3L4
Subcellular Location
Endoplasmic Reticulum; Golgi Apparatus; Nucleus
Tissue Specificity
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Bovine (91%), Horse (100%), Sheep (91%), Rabbit (100%), Dog (100%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of CREB3L4 using K562 whole cell lysates)
Western Blot (WB)
(Western blot analysis of CREB3L4 using K562 whole cell lysates)
Related Product Information for anti-CREB3L4 antibody
Function: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Subunit Structure: Binds DNA as a dimer.
Post-translational Modifications: N-glycosylated in the C-terminal region.Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
Similarity: Belongs to the bZIP family. ATF subfamily.
Subunit Structure: Binds DNA as a dimer.
Post-translational Modifications: N-glycosylated in the C-terminal region.Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
Similarity: Belongs to the bZIP family. ATF subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 43 kDa
Predicted: 44 kDa
Predicted: 44 kDa
NCBI Official Full Name
cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
NCBI Official Synonym Full Names
cAMP responsive element binding protein 3 like 4
NCBI Official Symbol
CREB3L4
NCBI Official Synonym Symbols
JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
NCBI Protein Information
cyclic AMP-responsive element-binding protein 3-like protein 4
UniProt Protein Name
Cyclic AMP-responsive element-binding protein 3-like protein 4
Protein Family
UniProt Gene Name
CREB3L4
UniProt Synonym Gene Names
AIBZIP; CREB4; JAL; cAMP-responsive element-binding protein 3-like protein 4; AIbZIP; ATCE1; CREB-4; cAMP-responsive element-binding protein 4; Tisp40
NCBI Description
This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements ().
Research Articles on CREB3L4
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Product Notes
The CREB3L4 creb3l4 (Catalog #AAA9609387) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CREB3L4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CREB3L4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the CREB3L4 creb3l4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CREB3L4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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