Low Density Lipoprotein Receptor-Related Protein (LRP) (515kDa) Monoclonal Antibody | anti-LRP1 antibody
MAb to Low Density LRP (515kDa)
Source: Ascites
Specifically reacts with the 515kDa alpha-chain of human LRP/alpha2 MR expressed in certain cell types. A strong immunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in the CNS, fibroblasts, smooth muscle cells and monocyte-derived foam cells in atherosclerotic lesions of arterial walls. Will block a2M binding.
Immunohistochemistry using paraffin and frozen sections: 1-10ug/ml.
Flow cytometry will recognize an epitope on the extracellular domain.
• Coukos, et al., (1994), Am. J. Pathology, 144, 383-392.
• Rebeck, et al., (1993), Neuron, 11, 575-580.
• Gonias, et al., (1992), Am. J. Path
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq]
Uniprot Description
LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: focal adhesion; clathrin-coated vesicle; cell soma; lysosomal membrane; integral to plasma membrane; cytoplasm; dendrite; nucleolus; plasma membrane; coated pit; receptor complex; endosome
Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity
Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; phototransduction, visible light; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; retinoid metabolic process; regulation of cholesterol transport; apoptotic cell clearance; aging
Research Articles on LRP1
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Product Notes
The LRP1 lrp1 (Catalog #AAA311046) is an Antibody produced from Host: Mouse Source: Ascites and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Low Density Lipoprotein Receptor-Related Protein (LRP) (515kDa) can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry, Immunohistochemistry - Formalin/Paraffin, Western Blot. Western Blot (non-reducing conditions): 1-5 ug/ml. Immunohistochemistry using paraffin and frozen sections: 1-10ug/ml. Flow cytometry will recognize an epitope on the extracellular domain. Researchers should empirically determine the suitability of the LRP1 lrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Low Density Lipoprotein Receptor-Related Protein (LRP) (515kDa), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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