Mouse anti-Human Lipoprotein Receptor-related Protein Associated Protein 1, Low Density Monoclonal Antibody | anti-LRPAP1 antibody
Lipoprotein Receptor-related Protein Associated Protein 1, Low Density (Low Density Lipoprotein Receptor-related Protein Associated Protein 1, LRPAP1, Alpha-2-macroglobulin Receptor-associated Protein, Alpha-2-MRAP, A2MRAP, A2RAP, HBP44, Lipoprotein Recep
Gene Names
LRPAP1; RAP; MRAP; A2RAP; HBP44; A2MRAP; MGC138272; LRPAP1
Reactivity
Human
Applications
Western Blot
Purity
Affinity PurifiedPurified by Protein A affinity chromatography.
Synonyms
Lipoprotein Receptor-related Protein Associated Protein 1; Low Density; Monoclonal Antibody; Low Density (Low Density Lipoprotein Receptor-related Protein Associated Protein 1; LRPAP1; Alpha-2-macroglobulin Receptor-associated Protein; Alpha-2-MRAP; A2MRAP; A2RAP; HBP44; Lipoprotein Recep; Anti -Lipoprotein Receptor-related Protein Associated Protein 1; anti-LRPAP1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
9L447
Specificity
Recognizes the 39kD low density lipoprotein receptor-associated protein (RAP). No cross-reaction with rabbit or mouse RAP.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in 0.05M sodium phosphate, 0.15M sodium chloride, pH 7.4. No preservative added.
Applicable Applications for anti-LRPAP1 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/ml
Dilution: Western Blot: 1ug/ml
Immunogen
Recombinant human RAP.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-LRPAP1 antibody
The low density lipoprotein receptor-related protein-associated protein 1 (LRPAP1/RAP) is an antagonist and molecular chaperone protein that binds tightly to low-density lipoprotein receptor family members and thereby prevents the binding of all known ligands, including alpha 2-macroglobulin and chylomicron remnants. RAP is present on the cell surface where it is an effective inhibitor of ligand binding to the kidney glycoprotein 330 (gp330), but is most abundant in the endoplasmic reticulum lumen and may function in receptor folding and/or trafficking.
Product Categories/Family for anti-LRPAP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
41,466 Da
NCBI Official Full Name
low density lipoprotein receptor-related protein associated protein 1 variant
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein associated protein 1
NCBI Official Symbol
LRPAP1
NCBI Official Synonym Symbols
RAP; MRAP; A2RAP; HBP44; A2MRAP; MGC138272; LRPAP1
NCBI Protein Information
alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
UniProt Protein Name
Alpha-2-macroglobulin receptor-associated protein
Protein Family
UniProt Gene Name
LRPAP1
UniProt Synonym Gene Names
A2MRAP
UniProt Entry Name
AMRP_HUMAN
NCBI Description
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Description
LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cell surface; endoplasmic reticulum; extracellular region; plasma membrane; integral to membrane; vesicle
Molecular Function: heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity
Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding
Disease: Myopia 23, Autosomal Recessive
Research Articles on LRPAP1
1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
2. Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta.
3. Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.
4. Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma
5. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
6. Observational study of genotype prevalence. (HuGE Navigator)
7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
8. Observational study of gene-disease association. (HuGE Navigator)
9. LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells.
10. alterations of the RAP gene are not a common cause of hypothyroidism
2. Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta.
3. Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.
4. Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma
5. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population.
6. Observational study of genotype prevalence. (HuGE Navigator)
7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
8. Observational study of gene-disease association. (HuGE Navigator)
9. LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells.
10. alterations of the RAP gene are not a common cause of hypothyroidism
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Product Notes
The LRPAP1 lrpap1 (Catalog #AAA608790) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Lipoprotein Receptor-related Protein Associated Protein 1, Low Density (Low Density Lipoprotein Receptor-related Protein Associated Protein 1, LRPAP1, Alpha-2-macroglobulin Receptor-associated Protein, Alpha-2-MRAP, A2MRAP, A2RAP, HBP44, Lipoprotein Recep reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lipoprotein Receptor-related Protein Associated Protein 1, Low Density can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1ug/ml. Researchers should empirically determine the suitability of the LRPAP1 lrpap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lipoprotein Receptor-related Protein Associated Protein 1, Low Density, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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