Mouse anti-Human LILRB3 Monoclonal Antibody | anti-LILRB3 antibody

Mouse anti Human LILRB3 Monoclonal Antibody

Cat. Num. AAA2543671

• Gene Names: LILRB3; HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6
• Reactivity: Human
• Applications: ELISA
• Synonyms: LILRB3; Monoclonal Antibody; Mouse anti Human LILRB3 Monoclonal Antibody; anti-LILRB3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 589

• Applicable Applications for anti-LILRB3 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug. This antibody can be used at 0.5-1 mug with the appropriate secondary reagents to detect Human LILRB3.
• Immunogen: Recombinant Human LILRB3 Protein
• Buffer: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human LILRB3 (rh LILRB3; NP_006855.2; Met 1-Glu 443). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 556523084
• NCBI GeneID: 11025
• Molecular Weight: 69,514 Da
• NCBI Official Full Name: LILRB3, partial
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor B3
• NCBI Official Symbol: LILRB3
• NCBI Official Synonym Symbols: HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 3
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 3
• Protein Family: Leukocyte immunoglobulin-like receptor subfamily
• UniProt Gene Name: LILRB3
• UniProt Synonym Gene Names: ILT5; LIR3; LIR-3; Leukocyte immunoglobulin-like receptor 3; ILT-5
• UniProt Entry Name: LIRB3_HUMAN

NCBI Description

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

LILRB3: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; receptor activity; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; defense response; negative regulation of osteoclast differentiation