CD85a recombinant protein

Recombinant Human CD85a protein, C-His Tag

Cat. Num. AAA1560554

• Gene Names: LILRB3; HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD85a; Recombinant Human CD85a protein; C-His Tag; LILRB3; CD85a recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human LILRB3 (Met1-Glu443) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD85a recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 574270893
• NCBI GeneID: 11025
• NCBI Accession #: NP_001074919.2
• NCBI GenBank Nucleotide #: NM_001081450.2
• UniProt Accession #: O75022; O15471; Q86U49; C9J1P3; C9JIP1
• Molecular Weight: 69,514 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor B3
• NCBI Official Symbol: LILRB3
• NCBI Official Synonym Symbols: HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily B member 3
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily B member 3
• UniProt Gene Name: LILRB3
• UniProt Synonym Gene Names: ILT5; LIR3; LIR-3; Leukocyte immunoglobulin-like receptor 3; ILT-5
• UniProt Entry Name: LIRB3_HUMAN

NCBI Description

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

LILRB3: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; receptor activity; transmembrane receptor activity

Biological Process: adaptive immune response; cell surface receptor linked signal transduction; defense response; negative regulation of osteoclast differentiation