Immunoassay (IA)
(The calibration curve of a sandwich assay for Leptin using 10-1757 as the capture antibody and 61-1010 as the biotinylated detection antibody.)
Mouse anti-Human Leptin Monoclonal Antibody | anti-LEP antibody
Mouse monoclonal Leptin antibody
Immunoassay (IA)
(The calibration curve of a sandwich assay for Leptin using 10-1757 as the capture antibody and 61-1010 as the biotinylated detection antibody.)
Immunoassay (IA)
(The calibration curve of a sandwich assay for Leptin using 10-1757 as the capture antibody and 61-1010 as the biotinylated detection antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]
Uniprot Description
leptin: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. Defects in LEP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the leptin family.
Protein type: Cell development/differentiation; Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q32.1
Cellular Component: extracellular region; extracellular space
Molecular Function: hormone activity; peptide hormone receptor binding
Biological Process: adult feeding behavior; angiogenesis; intestinal absorption; leptin-mediated signaling pathway; lipid metabolic process; negative regulation of appetite; negative regulation of autophagy; negative regulation of glucose import; placenta development; positive regulation of developmental growth; positive regulation of JAK-STAT cascade; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of T cell proliferation; positive regulation of TOR signaling pathway; prostaglandin secretion; regulation of angiogenesis; regulation of bone remodeling; regulation of cell cycle; regulation of endothelial cell proliferation; regulation of natural killer cell activation; regulation of natural killer cell mediated cytotoxicity; regulation of natural killer cell proliferation; regulation of nitric-oxide synthase activity; response to insulin stimulus; sexual reproduction; T cell differentiation; tyrosine phosphorylation of STAT protein
Disease: Leptin Deficiency
Research Articles on LEP
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Product Notes
The LEP lep (Catalog #AAA5306626) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse monoclonal Leptin antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Leptin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the LEP lep for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Leptin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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