Mouse KLF11 Monoclonal Antibody | anti-KLF11 antibody

KLF11 (Kruppel-like Factor 11, FKLF1, Transforming Growth Factor beta-Inducible Early Growth Response Protein 2, TGFb-Inducible Early Growth Response Protein 2, TIEG2)

Cat. Num. AAA600953

• Gene Names: KLF11; FKLF; FKLF1; MODY7; TIEG2; Tieg3
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: KLF11; Monoclonal Antibody; KLF11 (Kruppel-like Factor 11; FKLF1; Transforming Growth Factor beta-Inducible Early Growth Response Protein 2; TGFb-Inducible Early Growth Response Protein 2; TIEG2); Anti -KLF11 (Kruppel-like Factor 11; anti-KLF11 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8C207
• Specificity: Recognizes human KLF11.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-KLF11 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blotting.; Dilution: Western Blotting: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human KLF11
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Product Categories/Family for anti-KLF11 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 295148163
• NCBI GeneID: 8462
• NCBI Accession #: NP_001171189.1
• NCBI GenBank Nucleotide #: NM_001177718.1
• UniProt Accession #: O14901; Q9EPF4; Q53QU8
• Molecular Weight: 55,139 Da
• NCBI Official Full Name: Krueppel-like factor 11 isoform b
• NCBI Official Synonym Full Names: Kruppel-like factor 11
• NCBI Official Symbol: KLF11
• NCBI Official Synonym Symbols: FKLF; FKLF1; MODY7; TIEG2; Tieg3
• NCBI Protein Information: Krueppel-like factor 11; TIEG-2; OTTHUMP00000147532; TGFB-inducible early growth response protein 2; transforming growth factor-beta-inducible early growth response protein 2
• UniProt Protein Name: Krueppel-like factor 11
• Protein Family: Krueppel-like factor
• UniProt Gene Name: KLF11
• UniProt Synonym Gene Names: FKLF; TIEG2
• UniProt Entry Name: KLF11_HUMAN

NCBI Description

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

TIEG2: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: nucleus

Molecular Function: metal ion binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; apoptosis; positive regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter

Disease: Maturity-onset Diabetes Of The Young, Type 7