Mouse Kir2.3 K+ Channel Monoclonal Antibody | anti-Kcnj4 antibody
Anti-Kir2.3 K+ Monoclonal Antibody
Gene Names
Kcnj4; IRK3; Kcnf2; MB-IRK3
Reactivity
Human, mouse, rat
Applications
Immunoblot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Synonyms
Kir2.3 K+ Channel; Monoclonal Antibody; Anti-Kir2.3 K+ Monoclonal Antibody; anti-Kcnj4 antibody
Host
Mouse
Reactivity
Human, mouse, rat
Clonality
Monoclonal
Isotype
lgG1
Clone Number
S25-35
Specificity
Kir2.3 K+ Channel
This antibody recognizes human, mouse, and rat Kir2.3. It does not cross-react with Kir2.1 orKir2.2.
This antibody recognizes human, mouse, and rat Kir2.3. It does not cross-react with Kir2.1 orKir2.2.
Form/Format
100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Sequence Positions
390-445
Applicable Applications for anti-Kcnj4 antibody
Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence
Application Notes
Immunoblotting: use at 1-10ug/ml. A band of ~45kDa is detected. Immunohistochemistry and Immunocytochemistry. use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate.
Antigen
Fusion protein aa 390-445 of human Kir2.3 (accession number NP_032453).
Dilution Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Related Product Information for anti-Kcnj4 antibody
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. The protein encoded by the Kir2.3 gene is an integral membrane protein and a member of the inward rectifier otassium channel family. The Kir2.3 protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have identified.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,899 Da
NCBI Official Full Name
inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 4
NCBI Official Symbol
Kcnj4
NCBI Official Synonym Symbols
IRK3; Kcnf2; MB-IRK3
NCBI Protein Information
inward rectifier potassium channel 4; IRK-3; Kir 2.3; inward rectifier K(+) channel Kir2.3; potassium channel, inwardly rectifying subfamily J member 4
UniProt Protein Name
Inward rectifier potassium channel 4
Protein Family
UniProt Gene Name
Kcnj4
UniProt Synonym Gene Names
Irk3
UniProt Entry Name
IRK4_MOUSE
Uniprot Description
HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.
Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral
Cellular Component: postsynaptic membrane; membrane; cell soma; basolateral plasma membrane; integral to plasma membrane; dendrite; plasma membrane; integral to membrane; synapse; cytoplasmic vesicle; cell junction
Molecular Function: voltage-gated ion channel activity; inward rectifier potassium channel activity; PDZ domain binding
Biological Process: potassium ion import; transport; ion transport; potassium ion transport
Research Articles on Kcnj4
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Product Notes
The Kcnj4 kcnj4 (Catalog #AAA190581) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 390-445. The Anti-Kir2.3 K+ Monoclonal Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's Kir2.3 K+ Channel can be used in a range of immunoassay formats including, but not limited to, Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence. Immunoblotting: use at 1-10ug/ml. A band of ~45kDa is detected. Immunohistochemistry and Immunocytochemistry. use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate. Researchers should empirically determine the suitability of the Kcnj4 kcnj4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kir2.3 K+ Channel, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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