Mouse KIFAP3 Monoclonal Antibody | anti-KIFAP3 antibody

KIFAP3 Mouse Monoclonal

Cat. Num. AAA7600805

• Gene Names: KIFAP3; FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: KIFAP3; Monoclonal Antibody; KIFAP3 Mouse Monoclonal; anti-KIFAP3 antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 752

• Applicable Applications for anti-KIFAP3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Kinesin-associated protein 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human testis tissue slide using MBS7600805 (KIFAP3 Antibody) at dilution of 1:50)

Western Blot (WB)

(human testis tissue were subjected to SDS PAGE followed by western blot with MBS7600805 (KIFAP3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 325197195
• NCBI GeneID: 22920
• NCBI Accession #: NP_001191446.1
• NCBI GenBank Nucleotide #: NM_001204517.1
• Molecular Weight: 82,144 Da
• NCBI Official Full Name: kinesin-associated protein 3 isoform 4
• NCBI Official Synonym Full Names: kinesin associated protein 3
• NCBI Official Symbol: KIFAP3
• NCBI Official Synonym Symbols: FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1
• NCBI Protein Information: kinesin-associated protein 3
• UniProt Protein Name: Kinesin-associated protein 3
• Protein Family: Kinesin-associated protein
• UniProt Gene Name: KIFAP3
• UniProt Synonym Gene Names: KIF3AP; SMAP; KAP-3; KAP3
• UniProt Entry Name: KIFA3_HUMAN

NCBI Description

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Description

KIFAP3: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: axoneme; centrosome; condensed nuclear chromosome; cytosol; endoplasmic reticulum; Golgi apparatus; kinesin II complex; microtubule cytoskeleton; photoreceptor connecting cilium; spindle microtubule

Molecular Function: kinesin binding; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based movement; microtubule-based process; negative regulation of apoptosis; negative regulation of cell proliferation; positive regulation of calcium-dependent cell-cell adhesion; protein complex assembly; protein localization; retrograde vesicle-mediated transport, Golgi to ER; signal transduction