Testing Data (TD)
(Species Reactivty with Ker-1. Samples are treated with Kera-tanase and Keratanase II prior to electrophoresis.)
Mouse Keratocan Monoclonal Antibody | anti-KERA antibody
Monocloncal Antibody to Keratocan (Clone Ker-1)
Testing Data (TD)
(Species Reactivty with Ker-1. Samples are treated with Kera-tanase and Keratanase II prior to electrophoresis.)
Testing Data (TD)
(Species Reactivty with Ker-1. Samples are treated with Kera-tanase and Keratanase II prior to electrophoresis.)
Western Blot (WB)
(Western Blot using anti-Keratocan at a concentration of 0.4 ug/mL)
Western Blot (WB)
(Western Blot using anti-Keratocan at a concentration of 0.4 ug/mL)
Testing Data (TD)
(Keratocan localisation in the Embryonic cornea on days 13,15, and 18.)
Testing Data (TD)
(Keratocan localisation in the Embryonic cornea on days 13,15, and 18.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
Uniprot Description
Function: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
Subcellular location: Secreted › extracellular space › extracellular matrix
By similarity.
Tissue specificity: Cornea. Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen. Ref.4
Post-translational modification: Binds keratan sulfate chains
By similarity.
Involvement in disease: The autosomal recessive cornea plana 2 (CNA2) [MIM:217300]: In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.6
Sequence similarities: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.Contains 10 LRR (leucine-rich) repeats.Contains 1 LRRNT domain.
Research Articles on KERA
Similar Products
Product Notes
The KERA kera (Catalog #AAA442013) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Keratocan can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). ELISA; Western Blot: recommended dilution 0.4 mg/mL; IHC. Researchers should empirically determine the suitability of the KERA kera for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Keratocan, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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