Mouse anti-Human KCNQ5 Monoclonal Antibody | anti-KCNQ5 antibody

KCNQ5 (Potassium Voltage-gated Channel Subfamily KQT Member 5, KQT-like 5, Potassium Channel Subunit alpha KvLQT5, Voltage-gated Potassium Channel Subunit Kv7.5) (PE)

Cat. Num. AAA6158489

• Gene Names: KCNQ5; Kv7.5; MRD46
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNQ5; Monoclonal Antibody; KCNQ5 (Potassium Voltage-gated Channel Subfamily KQT Member 5; KQT-like 5; Potassium Channel Subunit alpha KvLQT5; Voltage-gated Potassium Channel Subunit Kv7.5) (PE); anti-KCNQ5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 2E2
• Specificity: Recognizes human KCNQ5.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-KCNQ5 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Partial recombinant corresponding to aa833-933 from human KCNQ5 (NP_062816) with GST tag. MW of the GST tag alone is 26kD.
• Immunogen Sequence: QNLIRSTEELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFASDSLRTGRSRSSQSICKAGESTDALSLPHVKLK
• Conjugate: PE
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (37.11kD).)

Testing Data

(Detection limit for recombinant GST tagged KCNQ5 is ~0.1ng/ml as a capture antibody.)

Related Product Information for anti-KCNQ5 antibody

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-KCNQ5 antibody

Antibodies; Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 28373065
• NCBI GeneID: 56479
• NCBI Accession #: NP_062816
• NCBI GenBank Nucleotide #: NM_019842
• UniProt Accession #: Q9NR82
• Molecular Weight: 103 kDa
• NCBI Official Full Name: potassium voltage-gated channel subfamily KQT member 5 isoform 1
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily Q member 5
• NCBI Official Symbol: KCNQ5
• NCBI Official Synonym Symbols: Kv7.5; MRD46
• NCBI Protein Information: potassium voltage-gated channel subfamily KQT member 5
• UniProt Protein Name: Potassium voltage-gated channel subfamily KQT member 5
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNQ5
• UniProt Entry Name: KCNQ5_HUMAN

NCBI Description

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Description

Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity

Biological Process: synaptic transmission; protein complex assembly