Testing Data
(Immunocytochemistry analysis of immersion fixed human T helper 17 cells using MBS605727 (25ug/ml). Stained using 557-conjugated anti mouse antibody.)
Mouse anti-Human Interleukin 17F Monoclonal Antibody | anti-IL17F antibody
Interleukin 17F (IL-17F)
Dilution: Flow Cytometry (Intracellular): 2.5ug/10e6 cells using human peripheral blood mononuclear cells trested with PMA and calcium ionomycin, fixed with paraformaldehyde and permeabilized with saponin.
Immunocytochemistry: 8-25ug/ml using human TH17 cells treated with PMA.
Testing Data
(Immunocytochemistry analysis of immersion fixed human T helper 17 cells using MBS605727 (25ug/ml). Stained using 557-conjugated anti mouse antibody.)
Testing Data
(Immunocytochemistry analysis of immersion fixed human T helper 17 cells using MBS605727 (25ug/ml). Stained using 557-conjugated anti mouse antibody.)
Flow Cytometry (FC)
(Flow Cytometry (intercellular) analysis of human peripheral blood mononuclear cells using MBS605727 or isotype control, followed by PE-conjugated anti-mouse antibody.)
Flow Cytometry (FC)
(Flow Cytometry (intercellular) analysis of human peripheral blood mononuclear cells using MBS605727 or isotype control, followed by PE-conjugated anti-mouse antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq]
Uniprot Description
IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: extracellular space; extracellular region
Molecular Function: protein homodimerization activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine binding; cytokine activity
Biological Process: proteoglycan metabolic process; negative regulation of angiogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of interleukin-8 biosynthetic process; lymphotoxin A biosynthetic process; cytokine biosynthetic process; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; regulation of interleukin-2 biosynthetic process; cartilage development; regulation of interleukin-6 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
Disease: Candidiasis, Familial, 6
Research Articles on IL17F
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Product Notes
The IL17F il17f (Catalog #AAA605727) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Interleukin 17F (IL-17F) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 17F can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS). Suitable for use in Direct ELISA, Immunocytochemistry and Flow Cytometry. Dilution: Flow Cytometry (Intracellular): 2.5ug/10e6 cells using human peripheral blood mononuclear cells trested with PMA and calcium ionomycin, fixed with paraformaldehyde and permeabilized with saponin. Immunocytochemistry: 8-25ug/ml using human TH17 cells treated with PMA. Researchers should empirically determine the suitability of the IL17F il17f for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 17F, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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