Mouse anti-Human Interleukin-15 (IL-15) Monoclonal Antibody | anti-IL-15 antibody
Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15)
Reactivity
Human
Applications
ELISA
Purity
Protein G Affinity Purified
Synonyms
Interleukin-15 (IL-15); Monoclonal Antibody; Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15); Mouse Monoclonal Antibody to Human IL-15; Clone 5E8; anti-IL-15 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
5E8
Specificity
Reactive with recombinant human IL-15.
Purity/Purification
Protein G Affinity Purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.0
Sequence Length
162
Applicable Applications for anti-IL-15 antibody
ELISA (EIA)
Application Notes
Sandwich ELISA: In combination with anti-human IL-15 detection antibody clone B1H6 (Cat. No.: MBS592471), clone 5E8 can be used as capture antibody for quantitative measurement of IL-15 in ELISA.
Immunogen
Purified recombinant human IL-15
Target protein
Human IL-15
Fusion Myeloma
SP2/0
Reconstitution
Double distilled water is recommended to reconstitute the antibody to 1mg/mL.
Intended use
In combination with anti-human IL-15 detection antibody clone B1H6, clone 5E8 can be used as capture antibody for quantitative measurement of IL-15 in ELISA.
Preparation and Storage
Store at -20 degree C
Related Product Information for anti-IL-15 antibody
Interleukin (IL)-15 is an inflammatory cytokine that can induce tumor-necrosis factor-alpha, IL-1beta and inflammatory chemokines. It acts on T cells and natural killer cells through receptors on these cells. IL-15 and IL-2 share common receptor beta and gamma units (IL-15/IL-2Rbetagammac) and thus some overlapping functions in stimulating T-cell proliferation and cytokine secretion. However, both cytokines have its own specific receptor alpha (IL-15Ralpha or IL-2Ralpha) that links to distinct signaling pathways. For example, IL-15 can inhibit self-tolerance mediated by IL-2 mediated activation-induced T cell death, and promote CD8+ memory T-cell survival. Increased IL-15 expression has been reported in patients with psoriasis and other inflammatory autoimmune diseases. IL-15 exists as soluble form, as well as membrane-bound form in which it could be directly bound to the cellular membrane or presented by IL-15Ralpha receptor. The main mechanism of IL-15 signaling is trans-presentation which is initiated by IL-15 binding to IL-15Ralpha. The IL-15/IL-15Ralpha complex subsequently presents IL-15 to surrounding cells bearing IL-15Rbetagammac complex on their cell surface. Recent research showed that combined activation with IL-12, IL-15, and IL-18 can induce memory-like natural killer (NK) cells that live longer and exhibit enhanced functionality when they encounter a secondary stimulation. The progress has led to increased interest in using IL-15 for cancer therapy.
Product Categories/Family for anti-IL-15 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
interleukin-15
NCBI Official Synonym Full Names
interleukin 15
NCBI Official Symbol
Il15
NCBI Protein Information
interleukin-15
UniProt Protein Name
Interleukin-15
Protein Family
UniProt Gene Name
Il15
UniProt Synonym Gene Names
IL-15
UniProt Entry Name
IL15_RAT
NCBI Description
human homolog is a cytokine involved in the regulation of T and natural killer cell activation and proliferation [RGD, Feb 2006]
Uniprot Description
Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the IL-15/IL-21 family.
Research Articles on IL-15
Similar Products
Product Notes
The IL-15 il15 (Catalog #AAA592470) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal Antibody to Human Interleukin-15 (IL-15) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin-15 (IL-15) can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Sandwich ELISA: In combination with anti-human IL-15 detection antibody clone B1H6 (Cat. No.: MBS592471), clone 5E8 can be used as capture antibody for quantitative measurement of IL-15 in ELISA. Researchers should empirically determine the suitability of the IL-15 il15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin-15 (IL-15), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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