Testing Data (TD)
(Sandwich ELISA: In combination with anti-human IL-17A clone 4C1 coated ELISA plate, the anti-human IL-17A antibody clone 3H11, when conjugated with Biotin, can be used for quantitative measurement of human IL-17A in sandwich ELISA. The dynamic range of the standard curve is 1000pg/ml to 15.6pg/ml.)
Mouse IL-17A Monoclonal Antibody | anti-IL-17A antibody
Mouse monoclonal antibody to human IL-17A, Clone 3H11
Gene Names
IL17A; IL17; CTLA8; IL-17; CTLA-8; IL-17A
Reactivity
Human, others not tested
Applications
ELISA, Western Blot
Purity
Protein G affinity purified
Synonyms
IL-17A; Monoclonal Antibody; Mouse monoclonal antibody to human IL-17A; Clone 3H11; mAb anti-Human IL-17A; Mouse monoclonal antibody to human interleukin-17A (IL-17A); anti-IL-17A antibody
Host
Mouse
Reactivity
Human, others not tested
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
3H11
Specificity
Reactive with human IL-17A
Purity/Purification
Protein G affinity purified
Form/Format
Lyophilized from a solution in 0.01M PBS, pH 7.0
Sequence Length
155
Applicable Applications for anti-IL-17A antibody
Indirect ELISA (EIA), Western Blot (WB)
Application Notes
Indirect ELISA: The anti-human IL-17A antibody clone 3H11 reacts with recombinant human IL-17A.
Western blot: The anti-human IL-10 antibody clone 6D2 reacts with recombinant human IL-10 (Immunogen).
Western blot: The anti-human IL-10 antibody clone 6D2 reacts with recombinant human IL-10 (Immunogen).
Target Protein
Human IL-17A
Immunogen
Purified recombinant human IL-17A
Fusion Myeloma
SP2/0
Reconstitution
Double distilled water is recommended to reconstitute the antibody to 1mg/ml
Research Area
Cytokine, Inflammatory and auto-immune diseases.
Preparation and Storage
Store at -20°C
Testing Data (TD)
(Sandwich ELISA: In combination with anti-human IL-17A clone 4C1 coated ELISA plate, the anti-human IL-17A antibody clone 3H11, when conjugated with Biotin, can be used for quantitative measurement of human IL-17A in sandwich ELISA. The dynamic range of the standard curve is 1000pg/ml to 15.6pg/ml.)
Testing Data (TD)
(Sandwich ELISA: In combination with anti-human IL-17A clone 4C1 coated ELISA plate, the anti-human IL-17A antibody clone 3H11, when conjugated with Biotin, can be used for quantitative measurement of human IL-17A in sandwich ELISA. The dynamic range of the standard curve is 1000pg/ml to 15.6pg/ml.)
Related Product Information for anti-IL-17A antibody
IL-17A is an inflammatory cytokine produced by Th17 cells, a newly characterised group of CD4 T help cells that plays a role in autoimmune diseases and chronic inflammatory diseases. IL-23 is the main inducer of Th17 cell development. Other cytokines such as TGF-beta, IL-6 and IL-21 were also found to contribute to the procedure. IL-17A belongs to the IL-17 family which includes IL-17A, IL-17B, IL-17C, IL-17D and IL-17E. IL-17, like interferon-gamma, is a potent mediator of delayed-type reaction. IL-17 induces the secretion of many other pro-inflammatory cytokines and chemokines such as IL-6, IL-8, GM-CSF, G-CSF, TGF-beta, TNF-alpha, GRO-alpha, and MCP-1. IL-17 stimulates the expression of NF-kappaB, mitogen activated protein kinase, and prostaglandings by many cell types, and enhances the production of nitric oxide.
Product Categories/Family for anti-IL-17A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; CTLA-8; IL-17A
NCBI Protein Information
interleukin-17A
UniProt Protein Name
Interleukin-17A
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
NCBI Description
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Uniprot Description
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Research Articles on IL-17A
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Product Notes
The IL-17A il17a (Catalog #AAA592444) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse monoclonal antibody to human IL-17A, Clone 3H11 reacts with Human, others not tested and may cross-react with other species as described in the data sheet. AAA Biotech's IL-17A can be used in a range of immunoassay formats including, but not limited to, Indirect ELISA (EIA), Western Blot (WB). Indirect ELISA: The anti-human IL-17A antibody clone 3H11 reacts with recombinant human IL-17A. Western blot: The anti-human IL-10 antibody clone 6D2 reacts with recombinant human IL-10 (Immunogen). Researchers should empirically determine the suitability of the IL-17A il17a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-17A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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