Mouse Integrin alphaV, beta6 Monoclonal Antibody | anti-Itgav antibody

Integrin alphaV, beta6 (HRP)

Cat. Num. AAA6243846

• Gene Names: Itgav; CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
• Reactivity: Human, Mouse, Rat
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Integrin alphaV; beta6; Monoclonal Antibody; beta6 (HRP); anti-Itgav antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 2Q871
• Specificity: Recognizes mouse integrin alphaV beta6. Blocks activity against mouse and human alphaV beta6. Does not recognize alphaV or other alphaV integrins. Species Crossreactivity: human and rat. Because the antibody was raised in knockout mice, it is likely to recognize the receptor in other species.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).

• Applicable Applications for anti-Itgav antibody: Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Immunogen: Immunization of beta6 knockout mice with wild Type mouse keratinocytes.
• Conjugate: HRP
• Preparation and Storage: Store at -20 degree C.

Product Categories/Family for anti-Itgav antibody

Antibodies; Integrin

References

Cho, J.Y., et al., J. Clin. Invest. 113: 551-560 (2004). General Reference: 1. Ahmed, N., et al., J. Cellular Biochemistry 84: 675-686 (2002). 2. Jarad, G., et al., J. Biol. Chem. 277(49): 47,826-47,833 (2002). 3. Munger, J.S., et al., Cell 96(3): 319-328 (1999).

NCBI and Uniprot Product Information

• NCBI GI #: 154240716
• NCBI GeneID: 16410
• NCBI Accession #: NP_032428.2
• NCBI GenBank Nucleotide #: NM_008402.3
• UniProt Accession #: P43406; A2AKI6
• Molecular Weight: 115,360 Da
• NCBI Official Full Name: integrin alpha-V
• NCBI Official Synonym Full Names: integrin alpha V
• NCBI Official Symbol: Itgav
• NCBI Official Synonym Symbols: CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
• NCBI Protein Information: integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha
• UniProt Protein Name: Integrin alpha-V
• Protein Family: Integrin
• UniProt Gene Name: Itgav
• UniProt Entry Name: ITAV_MOUSE

NCBI Description

This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]

Uniprot Description

ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: filopodium membrane; cell surface; focal adhesion; membrane; microvillus membrane; integral to membrane; plasma membrane; intracellular; cytosol; nucleus; integrin complex; external side of plasma membrane

Molecular Function: voltage-gated calcium channel activity; opsonin binding; insulin-like growth factor I binding; protease binding; protein kinase C binding; extracellular matrix binding; protein heterodimerization activity; metal ion binding; fibronectin binding; peptide binding; receptor binding

Biological Process: negative regulation of lipid transport; focal adhesion formation; entry of virus into host cell; positive regulation of cell adhesion; T cell activation; cell-matrix adhesion; multicellular organismal development; negative chemotaxis; gonad morphogenesis; regulation of phagocytosis; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; angiogenesis; cell growth; cell adhesion; inflammatory response; cell differentiation; integrin-mediated signaling pathway; blood vessel development; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; detection of molecule of bacterial origin; cell-substrate adhesion; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; fertilization; negative regulation of low-density lipoprotein receptor biosynthetic process; release of sequestered calcium ion into cytosol; positive regulation of osteoblast proliferation; endothelial cell migration; apoptotic cell clearance; positive regulation of cell migration